Evidence map›Paper›PMID 38533299›Full record

ArticleBioMedicine2024

VKORC1 polymorphisms and complete resistance to vitamin K antagonists: About two cases.

Ilham Benyamna, Houda El Fissi, Fadoua Bouzid, Abdelhamid El Mousadik, Najat Alif

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PubMed Full text at PMC Publisher
In one paragraph

Article in BioMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ilham BenyamnaDepartment of Cardiology and Internal Medicine, Inezgane Provincial Hospital, Agadir, Morocco.
Houda El FissiLaboratory of Biotechnologies and valorization of Natural Resources, Biology Department, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Fadoua BouzidLaboratory of Biotechnologies and valorization of Natural Resources, Biology Department, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Abdelhamid El MousadikLaboratory of Biotechnologies and valorization of Natural Resources, Biology Department, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Najat AlifLaboratory of Biotechnologies and valorization of Natural Resources, Biology Department, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Université Ibn Zohr · MARégie Autonome Multi Services D'Agadir · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete resistance to vitamin K antagonists is a rare but serious condition. It can complicate therapeutic management, especially when direct oral anticoagulants cannot be used. Some single mutations in the VKORC1 gene have been identified in patients partially or completely resistant to vitamin K antagonists. We report the cases of two women in their fifties who presented an unexplained peripheral venous thrombosis. The aetiological assessment did not show any abnormalities. Genetic testing showed that both patients had the VKORC1 5417 GG genotype. The VKORC1 3673 genotype was GG in case 1 and GA in case 2. The two patients showed complete resistance to vitamin K antagonists which required a change in treatment with favourable outcomes. Our goal is to offer optimal care guided by a literature review.

Indexed as

MutationsResistance to vitamin K antagonistsVKORC1

Identifiers

PMID38533299
PMCPMC10962563
OpenAlexW4392293153

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.