Evidence map›Paper›PMID 38532491›Full record

ArticleVeterinary research2024

Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model.

Rosa Casais, Natalia Iglesias, Iker A Sevilla, Joseba M Garrido, Ana Balseiro, Mercedes Dominguez, Ramon A Juste

Open access · goldAbstract read
In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Rosa CasaisArea de Sanidad Animal, SERIDA, 33394, Gijon, Asturias, Spain.
Natalia IglesiasArea de Sanidad Animal, SERIDA, 33394, Gijon, Asturias, Spain.
Iker A SevillaDepartamento de Sanidad Animal, NEIKER-BRTA, 48160, Derio, Bizkaia, Spain.
Joseba M GarridoDepartamento de Sanidad Animal, NEIKER-BRTA, 48160, Derio, Bizkaia, Spain.
Ana BalseiroDepartamento de Sanidad Animal, Facultad de Veterinaria, Universidad de León, 24071, León, León, Spain.
Mercedes DominguezUnidad de Inmunología Microbiana, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220, Majadahonda, Madrid, Spain.
Ramon A JusteDepartamento de Sanidad Animal, NEIKER-BRTA, 48160, Derio, Bizkaia, Spain. rjuste@neiker.eus.ORCID http://orcid.org/0000-0001-6037-5873
Euskadiko Parke Teknologikoa · ESServicio Regional de Investigación y Desarrollo Agroalimentario · ESInstituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M. bovis heat-inactivated vaccine (HIMB) prompted to test whether it could also induce TRAIM. To this, we used a sarcoptic mange rabbit model. Twenty-four weaned rabbits were treated orally or subcutaneously with a suspension of either HIMB (10

Indexed as

Mycobacterium bovisScabiesTuberculosisAnimalsBCG VaccineEnzyme-Linked Immunosorbent AssayHumansImmunity, HumoralRabbitsVaccines, InactivatedBCG VaccineVaccines, Inactivatedkilled vaccineMycobacterium bovisSarcoptes scabieiscabiesserologytrained immunitytuberculosis

Identifiers

PMID38532491
PMCPMC10967094
OpenAlexW4393201455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.