Evidence map›Paper›PMID 38532469›Full record

ArticleVeterinary research2024

Interleukin-2 enhancer binding factor 2 negatively regulates the replication of duck hepatitis A virus type 1 by disrupting the RNA-dependent RNA polymerase activity of 3D polymerase.

Hao An, Xiaoli Yu, Jing Li, Fuyan Shi, Yumei Liu, Ming Shu, Zihan Li, Xiaohong Li, Wanwei Li, Junhao Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hao AnSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Xiaoli YuSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Jing LiSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Fuyan ShiSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Yumei LiuSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Ming ShuSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Zihan LiSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Xiaohong LiSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Wanwei LiSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China.
Junhao ChenSchool of Public Health, Weifang Medical University, Weifang, 261042, Shandong, China. jhchen@wfmc.edu.cn.ORCID http://orcid.org/0000-0003-0215-2297
Weifang Medical University · CN

Funding

Natural Science Foundation of Shandong Province 201910240196Natural Science Foundation of Shandong Province ZR2020QC079Shandong Provincial Youth Innovation Team Development Plan of Colleges and Universities Lu-JiaoShandong Provincial Youth Innovation Team Development Plan of Colleges and Universities No.2019-6-156
6 · The paper itself

Abstract

The interaction between viral components and cellular proteins plays a crucial role in viral replication. In a previous study, we showed that the 3'-untranslated region (3'-UTR) is an essential element for the replication of duck hepatitis A virus type 1 (DHAV-1). However, the underlying mechanism is still unclear. To gain a deeper understanding of this mechanism, we used an RNA pull-down and a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay to identify new host factors that interact with the 3'-UTR. We selected interleukin-2 enhancer binding factor 2 (ILF2) for further analysis. We showed that ILF2 interacts specifically with both the 3'-UTR and the 3D polymerase (3D

Indexed as

Hepatitis, Viral, AnimalHepatitis Virus, DuckPicornaviridae InfectionsPoultry DiseasesAnimalsDucksGene Expression RegulationInterleukin-2RNA-Dependent RNA PolymeraseRNA, ViralInterleukin-2RNA-Dependent RNA PolymeraseRNA, Viral3D polymerase3′—untranslated regionDuck hepatitis A virus type 1Interleukin-2 enhancer binding factor 2RNA-dependent RNA polymerase

Identifiers

PMID38532469
PMCPMC10967090
OpenAlexW4393201742

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.