Evidence map›Paper›PMID 38532463›Full record

ArticleWorld journal of surgical oncology2024

STIM1/SOX2 proteins are co-expressed in the tumor and microenvironmental stromal cells of pancreatic ductal adenocarcinoma and ampullary carcinoma.

Dina Sweed, Sara Mohamed Abd Elhamed, Hayam Abdel Samie Aiad, Nermine Ahmed Ehsan, Aiat Shaban Hemida, Marwa Mohammed Dawoud

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dina SweedPathology Department, National Liver Institute, Menoufia University, Shibin Al Koom, Egypt.
Sara Mohamed Abd ElhamedPathology Department, National Liver Institute, Menoufia University, Shibin Al Koom, Egypt.
Hayam Abdel Samie AiadPathology Department, Faculty of Medicine, Menoufia University, Shibin Al Koom, 32511, Egypt.
Nermine Ahmed EhsanPathology Department, National Liver Institute, Menoufia University, Shibin Al Koom, Egypt.
Aiat Shaban HemidaPathology Department, Faculty of Medicine, Menoufia University, Shibin Al Koom, 32511, Egypt.
Marwa Mohammed DawoudPathology Department, Faculty of Medicine, Menoufia University, Shibin Al Koom, 32511, Egypt. marwa.dawood@med.menofia.edu.eg.
Menoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (AAC) are lethal malignancies with modest benefits from surgery. SOX2 and STIM1 have been linked to anticancer activity in several human malignancies. This study included 94 tumor cases: 48 primary PDAC, 25 metastatic PDAC, and 21 primary AAC with corresponding non-tumor tissue. All cases were immunohistochemically stained for STIM1 and SOX2 and results were correlated with clinicopathologic data, patient survival, and BCL2 immunostaining results. Results revealed that STIM1 and SOX2 epithelial/stromal expressions were significantly higher in PDAC and AAC in comparison to the control groups. STIM1 and SOX2 expressions were positively correlated in the primary and metastatic PDAC (P = 0.016 and, P = 0.001, respectively). However, their expressions were not significantly associated with BCL2 expression. SOX2 epithelial/stromal expressions were positively correlated with the large tumor size in the primary AAC group (P = 0.052, P = 0.044, respectively). STIM1 stromal and SOX2 epithelial over-expressions had a bad prognostic impact on the overall survival of AAC (P = 0.002 and P = 0.001, respectively). Therefore, STIM1 and SOX2 co-expression in tumor cells and intra-tumoral stroma could contribute to the development of PDAC and AAC. STIM1/SOX2 expression is linked to a bad prognosis in AAC.

Indexed as

AdenocarcinomaAmpulla of VaterCarcinoma, Pancreatic DuctalPancreatic NeoplasmsHumansNeoplasm ProteinsPrognosisProto-Oncogene Proteins c-bcl-2SOXB1 Transcription FactorsStromal CellsStromal Interaction Molecule 1Neoplasm ProteinsProto-Oncogene Proteins c-bcl-2SOX2 protein, humanSOXB1 Transcription FactorsSTIM1 protein, humanStromal Interaction Molecule 1Ampullary carcinomaBCL2ImmunohistochemistryPancreatic ductal adenocarcinomaSOX2STIM1

Identifiers

PMID38532463
PMCPMC10964627
OpenAlexW4393195704

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.