Evidence map›Paper›PMID 38532399›Full record

ArticleJournal of nanobiotechnology2024

OCTN2- and ATB

Bo Tang, Qiuxiang Wang, Guowei Zhang, Aiwen Zhang, Lu Zhu, Rongrong Zhao, Hongwei Gu, Jie Meng, Junfang Zhang, Guihua Fang

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Bo Tang *School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Qiuxiang Wang *School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Guowei Zhang *Eye Institute, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Aiwen ZhangSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Lu ZhuSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Rongrong ZhaoSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China.
Hongwei GuEye Institute, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Jie MengEye Institute, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China.
Junfang ZhangEye Institute, Affiliated Hospital of Nantong University, Nantong, 226001, Jiangsu, China. junfangzh@126.com.
Guihua FangSchool of Pharmacy, Nantong University, 19 Qixiu Road, Nantong, 226001, Jiangsu, China. fangguihua@ntu.edu.cn.
Nantong University · CN

Funding

Jiangsu Planned Projects for Postdoctoral Research Funds 2021K271BJiangsu Provincial Research Hospital YJXYY202204Jiangsu's Mass Entrepreneurship and Innovation Program the Large Instruments Open Foundation of Nantong University KFJN2368Natural Science Foundation of Jiangsu Province BK20170445
6 · The paper itself

Abstract

Traditional eye drops are administered via topical instillation. However, frequent dosing is needed due to their relatively rapid precorneal removal and low ocular bioavailability. To address these issues, stearoyl L-carnitine-modified nanoemulsions (SC-NEs) were fabricated. The physicochemical properties of SC-NEs in terms of size, morphology, zeta potential, encapsulation efficiency, and in vitro drug release behavior were characterized. The cellular uptake and mechanisms of SC-NEs were comprehensively studied in human corneal epithelial cells and the stearoyl L-carnitine ratio in SC-NEs was optimized. The optimized SC-NEs could target the novel organic cation/carnitine transporter 2 (OCTN2) and amino acid transporter B (0 +) (ATB

Indexed as

Drug Delivery SystemsEpithelial CellsAnimalsBiological TransportCarnitineHumansRabbitsSolute Carrier Family 22 Member 5CarnitineSolute Carrier Family 22 Member 5Amino acid transporter B (0 +) (ATB0,+)Endotoxin-induced uveitisNanoemulsionsNovel organic cation/carnitine transporter 2 (OCTN2)Ocular drug bioavailabilityStearoyl l-carnitine

Identifiers

PMID38532399
PMCPMC10964573
OpenAlexW4393194571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.