Evidence map›Paper›PMID 38532133›Full record

ReviewNature computational science2024

Digital twins in medicine.

R Laubenbacher, B Mehrad, I Shmulevich, N Trayanova

Abstract readReview
In one paragraph

Review in Nature computational science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. The Mind From Within: Visceral Roots of Human Cognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  10. Review
  11. Review
  12. AI-based augmentation of oncology clinical trials.Nature reviews. Clinical oncology · 2026
    Review
  13. Article
  14. Article
  15. Review
  16. Translational barriers to digital twins in radiation oncology.Physics and imaging in radiation oncology · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

R LaubenbacherDepartment of Medicine, University of Florida, Gainesville, FL, USA. reinhard.laubenbacher@medicine.ufl.edu.ORCID 0000-0002-9143-9451
B MehradDepartment of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-5198-065X
I ShmulevichInstitute for Systems Biology, Seattle, WA, USA.
N TrayanovaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Funding

Multiscale modeling of the role of heme during invasive pulmonary aspergillosisR01AI135128 · NIAID · UNIVERSITY OF FLORIDA · PI REINHARD LAUBENBACHER, Borna Mehrad · 2018 to 2026
$4.9M
Artificial intelligence analysis of atrial remodeling evolution in patients with atrial fibrillation: Towards optimal ablation strategiesR01HL166759 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Eugene Kholmovski, David Spragg · 2023 to 2026
$3.2M
Infarct-related Ventricular Tachycardia Mechanisms: From Micro to ClinicalR01HL142496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI TRAYANOVA, NATALIA A. · 2019 to 2022
$3.1M
Mechanistic modeling of the innate immune responses of the human lung to understand the inter-individual heterogeneity of COVID-19 pneumoniaR01HL169974 · NHLBI · UNIVERSITY OF FLORIDA · PI REINHARD LAUBENBACHER, Borna Mehrad · 2023 to 2026
$2.9M
Prototype System for AML Digital TwinsR01CA270210 · NCI · INSTITUTE FOR SYSTEMS BIOLOGY · PI VESTEINN THORSSON · 2023 to 2026
$2.8M
NCI NIH HHS R01 CA270210NHLBI NIH HHS R01 HL142496NHLBI NIH HHS R01 HL166759NHLBI NIH HHS R01 HL169974NIAID NIH HHS R01 AI135128
6 · The paper itself

Abstract

Medical digital twins, which are potentially vital for personalized medicine, have become a recent focus in medical research. Here we present an overview of the state of the art in medical digital twin development, especially in oncology and cardiology, where it is most advanced. We discuss major challenges, such as data integration and privacy, and provide an outlook on future advancements. Emphasizing the importance of this technology in healthcare, we highlight the potential for substantial improvements in patient-specific treatments and diagnostics.

Indexed as

Biomedical ResearchCardiologyHealth FacilitiesHumansMedical OncologyPrecision Medicine

Identifiers

PMID38532133
PMCPMC11102043

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.