Evidence map›Paper›PMID 38532105›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Perturbations in inflammatory pathways are associated with shortness of breath profiles in oncology patients receiving chemotherapy.

Joosun Shin, Christine Miaskowski, Melisa L Wong, Patsy Yates, Adam B Olshen, Ritu Roy, Vasuda Dokiparthi, Bruce Cooper, Steven Paul, Yvette P Conley and 3 more

Abstract read
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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Joosun ShinSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.
Christine MiaskowskiSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.
Melisa L WongSchool of Medicine, University of California, San Francisco, CA, USA.
Patsy YatesFaculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia.
Adam B OlshenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Ritu RoyHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Vasuda DokiparthiSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.
Bruce CooperSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.
Steven PaulSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA.
Yvette P ConleySchool of Nursing, Univeristy of Pittsburgh, 3500 Victoria St, Pittsburgh, 15213, PA, USA.
Jon D LevineSchool of Medicine, University of California, San Francisco, CA, USA.
Marilyn J HammerDana-Farber Cancer Institute, Boston, MA, USA.
Kord KoberSchool of Nursing, University of California, 2 Koret Way - N631Y, San Francisco, CA, 94143-0610, USA. Kord.Kober@ucsf.edu.

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Symptoms Clusters in Oncology Patients Receiving ChemotherapyR01CA134900 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, MIASKOWSKI, CHRISTINE A. · 2009 to 2014
$5.9M
An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics ApproachR37CA233774 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOBER, KORD MICHAEL · 2019 to 2025
$4.8M
Advancing patient-centered decision making in older adults with lung cancer: Incorporating risk of functional decline into treatment discussionsK76AG064431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WONG, MELISA L · 2019 to 2023
$1.3M
NCATS NIH HHS UL1 TR000004NCI NIH HHS P30 CA082103NCI NIH HHS R01 CA134900NCI NIH HHS R37 CA233774NIA NIH HHS K76 AG064431
6 · The paper itself

Abstract

purposeOne plausible mechanistic hypothesis is the potential contribution of inflammatory mechanisms to shortness of breath. This study was aimed to evaluate for associations between the occurrence of shortness of breath and perturbations in inflammatory pathways.

methodsPatients with cancer reported the occurrence of shortness of breath six times over two cycles of chemotherapy. Latent class analysis was used to identify subgroups of patients with distinct shortness of breath occurrence profiles (i.e., none (70.5%), decreasing (8.2%), increasing (7.8%), high (13.5%)). Using an extreme phenotype approach, whole transcriptome differential gene expression and pathway impact analyses were performed to evaluate for perturbed signaling pathways associated with shortness of breath between the none and high classes. Two independent samples (RNA-sequencing (n = 293) and microarray (n = 295) methodologies) were evaluated. Fisher's combined probability method was used to combine these results to obtain a global test of the null hypothesis. In addition, an unweighted knowledge network was created using the specific pathway maps to evaluate for interconnections among these pathways.

resultsTwenty-nine Kyoto Encyclopedia of Genes and Genomes inflammatory signaling pathways were perturbed. The mitogen-activated protein kinase signaling pathway node had the highest closeness, betweenness, and degree scores. In addition, five common respiratory disease-related pathways, that may share mechanisms with cancer-related shortness of breath, were perturbed.

conclusionsFindings provide preliminary support for the hypothesis that inflammation contribute to the occurrence of shortness of breath in patients with cancer. In addition, the mechanisms that underlie shortness of breath in oncology patients may be similar to other respiratory diseases.

Indexed as

DyspneaNeoplasmsHumansDyspneaGene expressionInflammationNeoplasms

Identifiers

PMID38532105
PMCPMC11484916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.