ArticleSurgical endoscopy2024
Natural history of gastric leiomyoma.
Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 9 citations in OpenAlex.
- IGF2-associated tumor cells and APOE-positive macrophages define an imatinib resistance-associated niche in gastrointestinal stromal tumors.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Gastric Adenomas and Mimickers: A Review.Diagnostics (Basel, Switzerland) · 2026Review
- Rare co-occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature.Experimental and therapeutic medicine · 2026Article
- Development and validation of an ultrasound-based AI-radiomics model for diagnosing and risk-stratifying gastrointestional stromal tumors: a retrospective diagnostic study.BMC medical imaging · 2025Article
- Natural History of Gastric Subepithelial Tumors: Long-Term Outcomes and Surveillance Strategies.Journal of clinical medicine · 2025Review
- Ultrastructural and Immunohistochemical Study of a Gastric Bizarre Leiomyoma: Bizarre Nuclei and Prominent Cytoplasmic Processes Extending Into and Displacing the Stroma.Pathology international · 2025Article
- Article
- A new endoscopic treatment for gastric fundal subepithelial lesions using loop-assisted inversion and double suture technique.Scientific reports · 2025Article
- Mucosal snare resection-endoscopic submucosal excavation for gastric submucosal tumors: a retrospective study (with video).Frontiers in oncology · 2025Article
- Endoscopic resection of a giant irregular leiomyoma in fundus and cardia: A case report.World journal of gastrointestinal endoscopy · 2024Article
- Commentary on "Comparison between laparoscopic liver resection and open liver resection in patients with hepatocellular carcinoma with portal vein tumor thrombosis".Surgical endoscopy · 2024Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost gastric leiomyomas are asymptomatic and benign subepithelial tumors (SETs); however, some may increase in size or become symptomatic. Understanding their natural history is therefore important to their management. We investigated the natural history of histologically proven gastric leiomyomas.
methodsWe retrospectively reviewed histologically proven gastric leiomyoma cases at a tertiary center. The baseline characteristics of these cases were analyzed, and those with a follow-up period of at least 12 months without immediate resection were evaluated. The primary outcome was the frequency of size increase of more than 25% during the follow-up period, and the secondary outcome was the histopathologic results in cases that underwent resection.
resultsAmong the 231 patients with histologically proven gastric leiomyomas, the most frequent location was the cardia (77.1%), and the median size was 3 cm (IQR 2-4 cm). Eighty-four cases were followed up over a median period of 50.8 months (IQR 27.2-91.3 months). During the follow-up period, tumor size increased in two cases (2.4%). Surgical results showed that one case was leiomyoma, and the other was leiomyosarcoma. Among the remaining cases without change in size, 15 underwent surgical resection (n = 10) or endoscopic resection (n = 5), and all cases were confirmed as leiomyoma.
conclusionsMost gastric leiomyomas are benign SETs, and an increase in size is not frequent, even in large-sized cases. Close monitoring with routine follow-up without resection may be sufficient in cases of histologically proven gastric leiomyoma. However, in cases of ulceration or size increase, resection may be beneficial.
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