Evidence map›Paper›PMID 38532040›Full record

ArticlePsychopharmacology2024

Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing.

Inês Macedo, Tiago O Paiva, Rita Pasion, Laura Daedelow, Andreas Heinz, Ana Magalhães, Tobias Banaschewski, Arun L W Bokde, Sylvane Desrivières, Herta Flor and 21 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 19 institutions in 9 countries.

Inês MacedoLaboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences (Laboratory of Neuropsychophysiology), University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal. macedo.iines@gmail.com.ORCID http://orcid.org/0000-0003-4792-9864
Tiago O PaivaHEI-LAB, Lusófona University, Porto, Portugal.
Rita PasionHEI-LAB, Lusófona University, Porto, Portugal.
Laura DaedelowDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin, Institute of Health, Berlin, Germany.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin, Institute of Health, Berlin, Germany.
Ana MagalhãesAddiction Biology Group, i3S-Instituto de Investigação E Inovação Em Saúde, Porto, Portugal.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-Sur-Yvette, France.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, 05405, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt, Braunschweig und Berlin, Germany.
Jean-Luc MartinotInstitut National de La Santé Et de La Recherche Médicale, INSERM U 1299 Trajectoires Développementales & Psychiatrie, CNRS; EcoleNormaleSupérieure Paris-Saclay, Centre Borelli, University Paris-Saclay, Gif-Sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de La Santé Et de La Recherche Médicale, INSERM U 1299 Trajectoires Développementales & Psychiatrie, University Paris-Saclay, CNRS; Ecole Normale Supérieure Paris-Saclay, Centre Borelli; Gif-Sur-Yvette, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, and AP-HP. Sorbonne University, Paris, France.
Eric ArtigesInstitut National de La Santé Et de La Recherche Médicale, INSERM U 1299 Trajectoires Développementales & Psychiatrie, CNRS; EcoleNormaleSupérieure Paris-Saclay, Centre Borelli; Gif-Sur-Yvette; and Psychiatry Department, EPS Barthélémy Durand, University Paris-Saclay, Etampes, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-Sur-Yvette, France.
Tomáš PausDepartments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hosptalier, Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry Psychotherapy and Psychosomatics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin, Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin, Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin, Berlin, Germany.
Fernando BarbosaLaboratory of Neuropsychophysiology, Faculty of Psychology and Educational Sciences (Laboratory of Neuropsychophysiology), University of Porto, Rua Alfredo Allen, 4200-135, Porto, Portugal.
IMAGEN Consortium
Heidelberg University · DEHumboldt-Universität zu Berlin · DEUniversidade do Porto · PTCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRÉcole Normale Supérieure Paris-Saclay · FRTechnische Universität Dresden · DETrinity College Dublin · IEUniversidade Lusófona do Porto · PTCentre National de la Recherche Scientifique · FRCharité - Universitätsmedizin Berlin · DEFudan University · CNKing's College London · GBPhysikalisch-Technische Bundesanstalt · DEUniversität Hamburg · DEUniversity of Göttingen · DEUniversity of Mannheim · DEUniversity of Nottingham · GBUniversity of Toronto · CAUniversity of Vermont · US

Funding

Fundação para a Ciência e Tecnologia (FCT) 2021.06791.BDMedical Research Council MR/N000390/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1
6 · The paper itself

Abstract

rationaleFor decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research suggests that mental health problems associated with cannabis use may result from its effect on reward brain circuit, emotional processes, and cognition. However, findings are mostly derived from correlational studies and inconsistent, particularly in adolescents. OBJECTIVES AND

methodsUsing data from the IMAGEN study, participants (non-users, persistent users, abstinent users) were classified according to their cannabis use at 19 and 22 years-old. All participants were cannabis-naïve at baseline (14 years-old). Psychopathological symptoms, cognitive performance, and brain activity while performing a Monetary Incentive Delay task were used as predictors of substance use and to analyze group differences over time.

resultsHigher scores on conduct problems and lower on peer problems at 14 years-old (n = 318) predicted a greater likelihood of transitioning to cannabis use within 5 years. At 19 years of age, individuals who consistently engaged in low-frequency (i.e., light) cannabis use (n = 57) exhibited greater conduct problems and hyperactivity/inattention symptoms compared to non-users (n = 52) but did not differ in emotional symptoms, cognitive functioning, or brain activity during the MID task. At 22 years, those who used cannabis at both 19 and 22 years-old n = 17), but not individuals that had been abstinent for ≥ 1 month (n = 19), reported higher conduct problems than non-users (n = 17).

conclusionsImpairments in reward-related brain activity and cognitive functioning do not appear to precede or succeed cannabis use (i.e., weekly, or monthly use). Cannabis-naïve adolescents with conduct problems and more socially engaged with their peers may be at a greater risk for lighter yet persistent cannabis use in the future.

Indexed as

BrainCognitionRewardAdolescentFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMarijuana AbuseMarijuana UseMental HealthYoung AdultAdolescentsCannabisCognitionfMRILongitudinalPsychopathologyReward Processing

Identifiers

PMID38532040
PMCPMC11199211
OpenAlexW4393185512

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.