ArticleNature communications2024
Macroevolutionary dynamics of gene family gain and loss along multicellular eukaryotic lineages.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
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- Comparative genomics of different haplotypes in Ditylenchus destructor provides insights into their host preferences.Communications biology · 2026Article
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- A smartphone analogy to explore the origin of animals.The EMBO journal · 2026Review
- Outsourcing of energetically costly amino acids at the origin of animals.Nature communications · 2026Article
- GeneFamily: a comprehensive mammalian gene family database with extensive annotation and interactive visualization.Nucleic acids research · 2026Article
- Phylostratigraphic Analysis Reveals the Evolutionary Origins and Potential Role of New Genes in the Adaptive Evolution ofInternational journal of molecular sciences · 2026Article
- Genome-wide analysis of the ALDH superfamily inFrontiers in plant science · 2026Article
- Genome-wide identification and functional characterization ofFrontiers in plant science · 2026Article
- Interkingdom horizontal gene transfer in plants: a perspective on methodological limitations and evolutionary alternatives.Frontiers in plant science · 2026Article
- Evolution of the Metazoan Protein Domain Repertoire Revealed by a Birth-Death-Gain Model.Journal of molecular evolution · 2025Article
- Reconstructing Evolutionary Histories with Hierarchical Orthologous Groups.Journal of molecular evolution · 2025Review
- Genomes of the entomopathogenic nematode Steinernema hermaphroditum and its associated bacteria.Genetics · 2025Article
- Comprehensive Analysis of the ARF Gene Family Reveals Their Roles in Chinese Chestnut (Biology · 2025Article
- Genetic and Pathogenic Overlaps Between Autism Spectrum Disorder and Alzheimer's Disease: Evolutionary Features and Opportunities for Drug Repurposing.International journal of molecular sciences · 2025Article
- The mitochondrial uncoupling proteins in early-branching animals: comparative analysis and transcriptional response to temperature in the jellyfish Stomolophus sp.2.Journal of bioenergetics and biomembranes · 2025Article
- Adaptive loss of shortwave-sensitive opsins during cartilaginous fish evolution.Nature communications · 2025Article
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4 authors.
Funding
Abstract
The gain and loss of genes fluctuate over evolutionary time in major eukaryotic clades. However, the full profile of these macroevolutionary trajectories is still missing. To give a more inclusive view on the changes in genome complexity across the tree of life, here we recovered the evolutionary dynamics of gene family gain and loss ranging from the ancestor of cellular organisms to 352 eukaryotic species. We show that in all considered lineages the gene family content follows a common evolutionary pattern, where the number of gene families reaches the highest value at a major evolutionary and ecological transition, and then gradually decreases towards extant organisms. This supports theoretical predictions and suggests that the genome complexity is often decoupled from commonly perceived organismal complexity. We conclude that simplification by gene family loss is a dominant force in Phanerozoic genomes of various lineages, probably underpinned by intense ecological specializations and functional outsourcing.
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