ArticleNature communications2024
Silk fibroin hydrogel adhesive enables sealed-tight reconstruction of meniscus tears.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Bioactive 3D-Printed valve scaffold promoting valvular regeneration via immunomodulation and endothelialization.Bioactive materials · 2026Article
- Bioresorbable metal-free molecular magnets enable untethered organ monitoring.Nature materials · 2026Article
- Nonexpansive biodegradable matrix promotes blood vessel organoid development for neurovascular repair and functional recovery in ischaemic stroke.Nature biomedical engineering · 2026Article
- Multi-Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- [Advances in immunomodulatory strategies for meniscal regeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Thermosensitive Injectable Hydrogel Incorporating Telopeptide-Free Type I Collagen Promotes Cartilage Regeneration: An In Vivo Study.Tissue engineering and regenerative medicine · 2026Article
- Near infrared enhanced palladium loaded siraitia grosvenorii carbon dots amplify mitophagy for acute lung injury immunotherapy.Bioactive materials · 2026Article
- Meniscus Tissue Engineering Scaffolds: Biomaterials, Biofabrication, and Translation.Polymers · 2026Review
- Intra-Articular Injection of Parathyroid Hormone (1-34) Enhances Meniscal Healing at the Site of a Radial Tear in the Rabbit Medial Meniscus.International journal of molecular sciences · 2026Article
- Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing.Bioactive materials · 2026Article
- Spermidine-functionalized Janus hydrogel microneedles inhibit ferroptosis and promote healing of oral ulcers.Bioactive materials · 2026Article
- Bioorthogonally Active Silk Fibroin Patch Facilitate Immunomodulatory Prodrug Activation for Tissue Repair.Advanced healthcare materials · 2026Article
- Recent advances onFundamental research · 2026Review
- Catalytic Amyloids: Turning Fibrils Into Biocatalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Silk Fibroin Sheets Improve the Strength of Colon Anastomoses in Wistar Rats.Journal of functional biomaterials · 2026Article
- Harnessing Phase Separation for the Development of High-Performance Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dynamic adaptive coassembled sericin protein orchestrating stem cell development for nucleus pulposus regeneration.Science advances · 2026Article
- Celecoxib-Loaded "Nano-in-Nano" Hierarchical Delivery System: Structure-Driven Synergistic Optimization of Diffusion Efficiency and Mechanical Stability for Osteoarthritis Therapy.Drug design, development and therapy · 2026Article
- Programmable Macrophage Mimics for Inflammatory Meniscus Regeneration via Nanotherapy.Research (Washington, D.C.) · 2026Article
- Silk fibroin hydrogel adhesive combined with miR-455 modified framework nucleic acids/ROS-responsive CeORegenerative biomaterials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration. Supramolecular interactions of β-sheets and hydrogen bonds richened by phenylboronic acid-ionic liquid (PIL) result in enhanced wet adhesion, swelling resistance, and anti-fatigue capabilities, compared to neat silk fibroin gel. Besides, elimination of reactive oxygen species (ROS) by S-PIL10 further fortifies localized meniscus tear repair by affecting inflammatory microenvironment with dynamic borate ester bonds, and S-PIL10 continuously releases TGF-β1 for cell recruitment and bridging of defect edge. In vivo rabbit models functionally evidence the seamless and dense reconstruction of torn meniscus, verifying that the concept of meniscus adhesive is feasible and providing a promising revolutionary strategy for preclinical research to repair meniscus tears.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.