ArticleInternational journal of STD & AIDS2024
Homocysteine modifies the association of coronary stenosis and HIV infection in an inner city African American population.
Thorsten M Leucker, Tarek Harb, Gary Gerstenblith, David D Celentano, Efthymios Ziogos, Glenn Treisman, Raul N Mandler, Jag Khalsa, Man Charurat, Shenghan Lai and 1 more
Open access · greenAbstract read
In one paragraphArticle in International journal of STD & AIDS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors at 4 institutions in 1 country.
Thorsten M LeuckerDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2569-6617 Tarek HarbDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Gary GerstenblithDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
David D CelentanoDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Efthymios ZiogosDivision of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Glenn TreismanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Raul N MandlerNational Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Jag KhalsaDepartment of Microbiology, Immunology and Tropical Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.ORCID 0000-0002-6534-3616 Man CharuratInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Shenghan LaiDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0003-1340-9609 Hong LaiInstitute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USUniversity of Maryland, Baltimore · USGeorge Washington University · USNational Institutes of Health · US
Funding
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0MEffects of HIV, Cocaine, and Prolonged ART Use on Subclinical Cardiovascular DiseaseU01DA040325 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LAI, SHENGHAN · 2016 to 2024
$12.7MSubclinical Atherosclerosis in HIV plus Black Cocaine UsersR01DA012777 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 1999 to 2014
$8.2MHIV Infection, Cocaine Use and Coronary Artery Disease in HIV+ African AmericansR01DA025524 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2008 to 2012
$3.8MHIV, Cocaine &Regional Left Ventricular DysfunctionR01DA015020 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2002 to 2006
$3.4MLipoprotein (a) Modification of the Impact of HIV Infection on Atherosclerotic Cardiovascular DiseaseR01HL176322 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Thorsten M Leucker · 2024 to 2026
$2.1MChanges in Coronary Noncalcified Volume in Relation to Changes in Cocaine UseR01DA035632 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LAI, SHENGHAN · 2013 to 2015
$2.1MThe Impact of Cocaine Abstinence or Reduced Use on Radiomic Features of Noncalcified Coronary Plaques in HIV-Infected Cocaine Users with Silent Coronary Artery DiseaseR21DA048780 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LAI, SHENGHAN · 2019 to 2020
$436kNHLBI NIH HHS R01 HL176322NIAID NIH HHS P30 AI094189NIDA NIH HHS R01 DA012777NIDA NIH HHS R01 DA015020NIDA NIH HHS R01 DA025524NIDA NIH HHS R01 DA035632NIDA NIH HHS R21 DA048780NIDA NIH HHS U01 DA040325
6 · The paper itselfAbstract
BACKGROUND AND
aimsPeople with HIV (PWH) whose disease is controlled on anti-retroviral regimens remain at an increased risk for coronary artery disease (CAD). Traditional cardiovascular risk factors do not fully explain the residual risk in PWH suggesting contributions from nontraditional factors. Homocysteine (Hcy) may be one of these as prior work in adults without HIV demonstrate that Hcy may impair endothelial function by decreasing the availability of nitric oxide, promoting the development of atherosclerosis. In addition, plasma Hcy levels are higher in PWH than in individuals living without HIV. The aim of this study was to investigate whether Hcy levels influence the association between HIV and coronary stenosis in an inner city African American population.
methodsAfrican Americans from the Heart Study in Baltimore, with and without HIV, recruited from inner-city Baltimore between June 2004 and February 2015, were included in this analysis. Participants underwent coronary CT angiography to evaluate the presence of coronary stenosis, defined as luminal stenosis >10%. Hcy was measured from stored serum samples.
resultsIn this analysis, the median [IQR] age of the 664 participants was 56 [50-66] years; 68.1% were living with HIV and 43.1% were women. Elevated Hcy (>15 µmol/L) was more prevalent in those with coronary stenosis (23.3%, 95% CI: 18.4%-28.2%) than in those without coronary stenosis (13.1%, 95% CI: 9.7%-16.5%) (
conclusionsOur data suggest an association between elevated Hcy levels (>15 µmol/L) and the prevalence of coronary stenosis in PWH from this inner city African American population.
Indexed as
Black or African AmericanCoronary StenosisHIV InfectionsHomocysteineAgedBaltimoreCoronary AngiographyFemaleHumansMaleMiddle AgedRisk FactorsUrban PopulationHomocysteineCoronary stenosisHIV infectionHomocysteine
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PMID38531830
PMCPMC11908455
OpenAlexW4393229879
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