Evidence map›Paper›PMID 38531561›Full record

ArticleBMJ open2024

Effectiveness and cost-effectiveness of a web-based cardiac rehabilitation programme for people with chronic stable angina: protocol for the ACTIVATE (Angina Controlled Trial Investigating the Value of the 'Activate your heart' Therapeutic E-intervention) randomised controlled trial.

Nefyn H Williams, Brendan Collins, Terence J Comerford, Susanna Dodd, Michael Fisher, Ben Hardwick, Sophie Hennessy, Kate Jolly, Ian Jones, Deirdre Lane and 5 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Nefyn H WilliamsDepartment of Primary Care and Mental Health, University of Liverpool, Liverpool, UK nefyn.williams@liverpool.ac.uk.ORCID 0000-0002-8078-409X
Brendan CollinsDepartment of Public Health Policy and Systems, University of Liverpool, Liverpool, UK.
Terence J ComerfordPatient and Public Involvement, National Institute for Health and Care Research Applied Research Collaboration North West Coast, Liverpool, UK.
Susanna DoddDepartment of Health Data Science, University of Liverpool, Liverpool, UK.
Michael FisherLiverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
Ben HardwickLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Sophie HennessyLiverpool Clinical Trials Centre, University of Liverpool, Liverpool, UK.
Kate JollyInstitute of Applied Health Research, University of Birmingham, Birmingham, UK.ORCID 0000-0002-6224-2115
Ian JonesSchool of Nursing and Allied Health, Liverpool John Moores University, Liverpool, UK.
Deirdre LaneDepartment of Cardiovascular and Metabolic Medicine, University of Liverpool, Liverpool, UK.ORCID 0000-0002-5604-9378
Gregory Y H LipLiverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, Liverpool, UK.ORCID 0000-0002-7566-1626
Erica MorganPatient and Public Involvement, National Institute for Health and Care Research Applied Research Collaboration North West Coast, Liverpool, UK.
Penelope RalphDepartment of Primary Care and Mental Health, University of Liverpool, Liverpool, UK.
Dick ThijssenSchool of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Sally J SinghDepartment of Respiratory Sciences, University of Leicester, Leicester, UK.
University of Liverpool · GBLiverpool John Moores University · GBNational Institute for Health Research · GBUniversity of Birmingham · GBUniversity of Leicester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angina. However, there is insufficient evidence of effectiveness and cost-effectiveness for its routine use in this patient group. The objectives of this study are to compare the effectiveness and cost-effectiveness of the 'Activate Your Heart' cardiac rehabilitation programme for people with chronic stable angina compared with usual care. METHODS AND ANALYSIS: ACTIVATE is a multicentre, parallel-group, two-arm, superiority, pragmatic randomised controlled trial, with recruitment from primary and secondary care centres in England and Wales and a target sample size of 518 (1:1 allocation; allocation sequence by minimisation programme with built-in random element). The study uses secure web-based allocation concealment. The two treatments will be optimal usual care (control) and optimal usual care plus the 'Activate Your Heart' web-based cardiac rehabilitation programme (intervention). Outcome assessment and statistical analysis will be performed blinded; participants will be unblinded. Outcomes will be measured at baseline and at 6 and 12 months' follow-up. Primary outcome will be the UK version of Seattle Angina Questionnaire (SAQ-UK), physical limitations domain at 12 months' follow-up. Secondary outcomes will be the remaining two domains of SAQ-UK, dyspnoea, anxiety and depression, health utility, self-efficacy, physical activity and the incremental shuttle walk test. All safety events will be recorded, and serious adverse events assessed to determine whether they are related to the intervention and expected. Concurrent economic evaluation will be cost-utility analysis from health service perspective. An embedded process evaluation will determine the mechanisms and processes that explain the implementation and impacts of the cardiac rehabilitation programme. ETHICS AND DISSEMINATION: North of Scotland National Health Service Research Ethics Committee approval, reference 21/NS/0115. Participants will provide written informed consent. Results will be disseminated by peer-reviewed publication. TRIAL REGISTRATION NUMBER: ISRCTN10054455.

Indexed as

Angina, StableCardiac RehabilitationCost-Benefit AnalysisEquivalence Trials as TopicHumansInternetMulticenter Studies as TopicPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicState MedicineAdult cardiologyHEALTH ECONOMICSIschaemic heart diseasePrimary CareRandomized Controlled TrialREHABILITATION MEDICINE

Identifiers

PMID38531561
PMCPMC10966821
OpenAlexW4393203181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.