ReviewNeuroscience and biobehavioral reviews2024
The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia.
Review in Neuroscience and biobehavioral reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of meditation on clinical symptoms and gray matter volume in chronic schizophrenia: a randomized controlled trial.European archives of psychiatry and clinical neuroscience · 2026Trial
- Distributed Neural Substrates for Autonomic Control During Human Thermoregulation: Brain Network Configurations of Sympathetic and Parasympathetic Innervation.Brain topography · 2026Article
- Decision processes in 3D structural MRI schizophrenia classification evaluated with saliency maps.Scientific reports · 2026Article
- Common and distinct neurofunctional signatures of dynamic naturalistic emotion regulation strategies.Nature communications · 2026Article
- Attenuated inferred-sensory mismatch during masked face recognition in schizophrenia.Frontiers in psychiatry · 2026Article
- Neuroanatomical correlates of psychiatric manifestations in Wilson disease: the role of age.Frontiers in psychiatry · 2026Article
- A novel strategy for enhanced schizophrenia detection using established CNN architectures.BMC medical imaging · 2025Article
- Alterations in functional connectivity analyzed using MREG in patients with suspected autoimmune psychosis spectrum syndromes.Brain, behavior, & immunity - health · 2025Article
- A two-year longitudinal investigation of insula subregional cortical thickness and surface area in early psychosis.Schizophrenia research · 2025Article
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Brain structural differences between fibromyalgia patients and healthy control subjects: a source-based morphometric study.Scientific reports · 2025Article
- Structural and functional changes of insula subregions in migraine without aura and their relationships with pain perception.Scientific reports · 2025Article
- Editorial: Neuroimaging in psychiatry 2023: schizophrenia.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Schizophrenia is a highly heterogeneous disorder characterized by a multitude of complex and seemingly non-overlapping symptoms. The insular cortex has gained increasing attention in neuroscience and psychiatry due to its involvement in a diverse range of fundamental human experiences and behaviors. This review article provides an overview of the insula's cellular and anatomical organization, functional and structural connectivity, and functional significance. Focusing on specific insula subregions and using knowledge gained from humans and preclinical studies of insular tracings in non-human primates, we review the literature and discuss the functional roles of each subregion, including in somatosensation, interoception, salience processing, emotional processing, and social cognition. Building from this foundation, we then extend these findings to discuss reported abnormalities of these functions in individuals with schizophrenia, implicating insular involvement in schizophrenia pathology. This review underscores the insula's vast role in the human experience and how abnormal insula structure and function could result in the wide-ranging symptoms observed in schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.