Evidence map›Paper›PMID 38531323›Full record

ArticleAnnals of nutrition & metabolism2024

Large Neutral Amino Acids Moderate the Effects of Metabolic Syndrome on Cognitive Performance in Middle-Aged Adults.

Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Dietmar Fuchs, Hirofumi Tanaka, Andreana P Haley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nutrition & metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Cherry YounDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Marie L CaillaudDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Yanrong LiDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Isabelle A GallagherDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Barbara StrasserDepartment of Medicine, Sigmund Freud University Vienna, Vienna, Austria.
Dietmar FuchsInstitute of Biological Chemistry, Biocentre, Medical University of Innsbruck, Innsbruck, Austria.
Hirofumi TanakaDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, USA.
Andreana P HaleyDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
The University of Texas at Austin · USInnsbruck Medical University · AT

Funding

Neuroimaging Cognitive Vulnerability in HypertensionR01NS075565 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HALEY, ANDREANA PETROVA · 2011 to 2013
$986k
NINDS NIH HHS R01 NS075565
6 · The paper itself

Abstract

introductionTwo large neutral amino acids (LNAA), tryptophan and tyrosine, are precursors to cerebral neurotransmitters and are involved in cognitive function. Higher levels of LNAA in young adults are associated with improved cognition, although these associations appear to reverse over time. Given that exposure to metabolic syndrome (MetS) may induce premature cognitive aging, the current project aims to fill the gap in the literature by examining the effect of LNAA on cognitive performance in midlife adults with metabolic risks.

methodsEighty-eight adults, ages 40-61 years, participated in this cross-sectional study. LNAA metabolites were quantified, MetS components were measured using high-performance liquid chromatography, and MetS components were assessed in the laboratory. Composite verbal memory and executive functioning scores were computed using principal component analysis. We used linear regression models to test the interaction between LNAA and MetS while covarying for sex, age, and education.

resultsThe kynurenine/tryptophan ratio moderated the relation between MetS and verbal memory, even after adjusting for relevant covariates. Tyrosine metabolites were not significant moderators of the association between MetS and executive functioning.

conclusionOur findings suggest that the detected weaker memory performance in adults with a high number of MetS components may be related to relative tryptophan depletion and possible decreases in serotonin production. Further investigation is warranted to examine the potential role of LNAA in associations between cognitive performance and metabolic risks over time.

Indexed as

CognitionExecutive FunctionMetabolic SyndromeTryptophanAdultAmino Acids, NeutralCross-Sectional StudiesFemaleHumansKynurenineMaleMemoryMiddle AgedTyrosineAmino Acids, NeutralKynurenineTryptophanTyrosineCognitive performanceLarge neutral amino acidsMetabolic syndromeMidlife adults

Identifiers

PMID38531323
PMCPMC11305933
OpenAlexW4393216370

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.