Evidence map›Paper›PMID 38531125›Full record

ArticleJournal of behavior therapy and experimental psychiatry2024

Externally orienting cues improve cognitive control in OCD.

Lora Bednarek, Stephanie Glover, Xiao Ma, Christopher Pittenger, Helen Pushkarskaya

Open access · greenAbstract read
In one paragraph

Article in Journal of behavior therapy and experimental psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.6field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lora BednarekDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States.
Stephanie GloverPGSP-Stanford PsyD Consortium, Palo Alto University, Palo Alto, CA, United States.
Xiao MaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States.
Christopher PittengerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States; Department of Psychology, Yale University, New Haven, CT, United States; Yale Child Study Center, Yale School of Medicine, New Haven, CT, United States; Wu Tsai Institute, Yale University, New Haven, CT, United States; Yale Center for Brain and Mind Health, Yale School of Medicine, New Haven, CT, United States.
Helen PushkarskayaDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, United States. Electronic address: helen.pushkarskaya@yale.edu.
Yale University · USPalo Alto University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Glutamate in OCD: a magnetic resonance spectroscopy study.R01MH095790 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2012 to 2016
$1.8M
Patient Oriented Research and Mentorship and Training in Functional Neuroimaging of Obsessive-Compulsive DisorderK24MH121571 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2020 to 2024
$900k
Neural correlates of Uncertainty Intolerance in Obsessive Compulsive DisorderK01MH101326 · NIMH · YALE UNIVERSITY · PI PUSHKARSKAYA, HELEN · 2014 to 2017
$731k
Evidence accumulation in obsessive-compulsive disorder during perceptual and value-based decisionsR21MH115394 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN, PUSHKARSKAYA, HELEN · 2018 to 2019
$461k
Characterizing Reference Distribution of Key Parameters of Drift Diffusion Model of Perceptual and Value-Based DecisionsR21MH120801 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN, PUSHKARSKAYA, HELEN · 2019 to 2020
$404k
NCATS NIH HHS UL1 TR001863NIMH NIH HHS K01 MH101326NIMH NIH HHS K24 MH121571NIMH NIH HHS R01 MH095790NIMH NIH HHS R21 MH115394NIMH NIH HHS R21 MH120801
6 · The paper itself

Abstract

BACKGROUND AND

objectivesAn executive overload model of obsessive-compulsive disorder (OCD) posits that broad difficulties with executive functioning in OCD result from an overload on the executive system by obsessive thoughts. It implies that, if individuals with OCD "snap out" of their obsessive thoughts, their performance on neurocognitive tasks will improve.

methodsWe test this prediction using the revised Attention Network Test, ANT-R, and distinct subsamples of data from unmedicated OCD and healthy controls (HC). ANT-R includes Simon and Flanker tasks; in both, incongruent trials take longer to resolve ('conflict costs'). On some trials, a warning cue helps participants to respond faster ('alerting benefits'). In OCD (N = 34) and HC (N = 46), matched on age, IQ, and sex, we tested (1) the effect of OCD on alerting benefits, and (2) the effect of OCD on warning cue related reductions in conflict costs. In a distinct subsample of OCD (N = 32) and HC (N = 51), we assessed whether alerting benefits and cue-related reductions in conflict costs are associated differently with different OCD symptoms.

resultsA warning cue can help individuals with OCD more than HC to improve performance on Simon and Flanker tasks. This effect is positively associated with severity of contamination symptoms. LIMITATIONS: This study did not directly assess how distracted participants are by obsessive thoughts. It relied on the ANT-R subtraction measures. Symptom severity was assessed using self-report measures.

conclusionsDifficulties in resolving conflict during decision-making in OCD can be modulated by a warning cue presented immediately before an attentional task.

Indexed as

CuesExecutive FunctionObsessive-Compulsive DisorderAdultAttentionFemaleHumansMaleMiddle AgedNeuropsychological TestsReaction TimeYoung AdultExecutive functioningExecutive overload modelExposure and response prevention (ERP) therapiesObsessive-compulsive disorderRevised attention network test

Identifiers

PMID38531125
PMCPMC11192454
OpenAlexW4392820610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.