Evidence map›Paper›PMID 38530968›Full record

ArticleMacromolecular rapid communications2025

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials.

Moniek G J Schmitz, Jasper G M Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J M Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A J Zaat and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Moniek G J SchmitzDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Jasper G M AartsDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Laurence BurroughsSchool of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Phanikrishna SudarsanamDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Tim J M KuijpersDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Martijn RioolDepartment of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
Leonie de BoerDepartment of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
Xuan XueSchool of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Dragan BosnackiDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Sebastian A J ZaatDepartment of Medical Microbiology and Infection Prevention, Amsterdam institute for Infection and Immunity, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands.
Jan de BoerDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Morgan R AlexanderSchool of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Patricia Y W DankersDepartment of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.ORCID https://orcid.org/0000-0002-8997-181X

Funding

Dutch Polymer Institute 731.015.505HORIZON EUROPE Widening Participation and Strengthening the European Research Area 101079482Ministerie van Onderwijs, Cultuur en Wetenschap 024.003.013Ministerie van Onderwijs, Cultuur en Wetenschap 024.005.020
6 · The paper itself

Abstract

A polymer microarray based on the supramolecular ureido-pyrimidinone (UPy) moiety is fabricated to screen antimicrobial materials for their ability to support cell adhesion. UPy-functionalized additives, either cell-adhesive, antimicrobial or control peptides, are used, and investigated in different combinations at different concentrations, resulting in a library of 194 spots. These are characterized on composition and morphology to evaluate the microarray fabrication. Normal human dermal fibroblasts are cultured on the microarrays and cell adhesion to the spots is systematically analyzed. Results demonstrate enhanced cell adhesion on spots with combinations including the antimicrobial peptides. This study clearly proves the power of the high throughput approach in combination with supramolecular molecules, to screen additive libraries for desired biological response.

Indexed as

Anti-Infective AgentsBiocompatible MaterialsHigh-Throughput Screening AssaysPolymersCell AdhesionFibroblastsHumansMacromolecular SubstancesMolecular StructureAnti-Infective AgentsBiocompatible MaterialsMacromolecular SubstancesPolymersantimicrobialarraybiomaterialshigh throughputscreeningsupramolecularupy

Identifiers

PMID38530968
PMCPMC12004893

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.