Evidence map›Paper›PMID 38530677›Full record

ReviewThe Journal of investigative dermatology2024

Adding Fuel to the Fire? The Skin Microbiome in Atopic Dermatitis.

Sara Saheb Kashaf, Heidi H Kong

Open access · bronzeAbstract readReview
In one paragraph

Review in The Journal of investigative dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Atopic dermatitis.Nature reviews. Disease primers · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Skin microbiome and dermatologic disorders.The Journal of clinical investigation · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sara Saheb KashafNational Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA; Pritzker School of Medicine, The University of Chicago, Chicago, Illinois, USA.
Heidi H KongNational Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: heidi.kong@nih.gov.
National Institutes of Health · US

Funding

Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant (Parent T32)T32HD007009 · NICHD · UNIVERSITY OF CHICAGO · PI NANCY B SCHWARTZ · 1985 to 2026
$13.0M
Studies of human microbes and potential perturbationsZIAAR041219 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$4.3M
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIAAR041217 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2023
$1.2M
Investigation of the natural history and pathogenesis of skin diseasesZIAAR041218 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$745k
Intramural NIH HHS Z99 AR999999Intramural NIH HHS ZIA AR041217NICHD NIH HHS T32 HD007009
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a multifactorial, heterogeneous disease characterized by epidermal barrier dysfunction, immune system dysregulation, and skin microbiome alterations. Skin microbiome studies in AD have demonstrated that disease flares are associated with microbial shifts, particularly Staphylococcus aureus predominance. AD-associated S. aureus strains differ from those in healthy individuals across various genomic loci, including virulence factors, adhesion proteins, and proinflammatory molecules-which may contribute to complex microbiome barrier-immune system interactions in AD. Different microbially based treatments for AD have been explored, and their future therapeutic successes will depend on a deeper understanding of the potential microbial contributions to the disease.

Indexed as

Dermatitis, AtopicMicrobiotaSkinStaphylococcus aureusHumansAtopic dermatitisBacteriaMicrobiomeSkinStaphylococcus

Identifiers

PMID38530677
PMCPMC11034722
OpenAlexW4393191413

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.