Evidence map›Paper›PMID 38530530›Full record

ArticleAnnals of surgical oncology2024

The Prognostic Role of the Number of Involved Structures in Thymic Epithelial Tumors: Results from the ESTS Database.

Marco Chiappetta, Filippo Lococo, Carolina Sassorossi, Clemens Aigner, Till Ploenes, Dirk Van Raemdonck, Cedric Vanluyten, Paul Van Schil, Apostolos C Agrafiotis, Francesco Guerrera and 13 more

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Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Marco ChiappettaUniversità Cattolica del Sacro Cuore, Rome, Italy. marco.chiappetta@policlinicogemelli.it.
Filippo LococoUniversità Cattolica del Sacro Cuore, Rome, Italy.
Carolina SassorossiUniversità Cattolica del Sacro Cuore, Rome, Italy.
Clemens AignerDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Till PloenesDivision of Thoracic Surgery, Department of Visceral, Thoracic and Vascular Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Dirk Van RaemdonckDepartment of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium.
Cedric VanluytenDepartment of Thoracic Surgery, University Hospital Gasthuisberg, Leuven, Belgium.
Paul Van SchilDepartment of Thoracic and Vascular Surgery, Antwerp University Hospital and Antwerp University, Antwerp, Belgium.
Apostolos C AgrafiotisDepartment of Thoracic and Vascular Surgery, Antwerp University Hospital and Antwerp University, Antwerp, Belgium.
Francesco GuerreraThoracic Surgery Unit, Department of Surgical Sciences, University of Turin, Turin, Italy.
Paraskevas LyberisThoracic Surgery Unit, Department of Surgical Sciences, University of Turin, Turin, Italy.
Monica CasiraghiDivision of Thoracic Surgery, IEO, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Lorenzo SpaggiariDivision of Thoracic Surgery, IEO, Istituto Europeo di Oncologia, IRCCS, Milan, Italy.
Charalambos ZisisDepartment of Thoracic Surgery, Chest Disease Hospital "Sotiria", Athens, Greece.
Christina MagouDepartment of Pathology, Evangelismos Hospital, Athens, Greece.
Bernhard MoserHead ESTS Thymic Working Group, Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Jonas BauerDepartment of Thoracic Surgery, Medical University of Vienna, Vienna, Austria.
Pascal Alexandre ThomasDepartment of Thoracic Surgery, North Hospital, APHM, Aix-Marseille University, Marseille, France.
Geoffrey BrioudeDepartment of Thoracic Surgery, North Hospital, APHM, Aix-Marseille University, Marseille, France.
Stefano PassaniKData Clinical srl, Rome, Italy.
Zalan ZsantoDepartment of Surgery Medical School, University of Pécs, Pecs, Hungary.
Isabella SperdutiBiostatistics, Regina Elena National Cancer Institute - IRCCS, Rome, Italy.
Stefano MargaritoraUniversità Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of the number of involved structures (NIS) in thymic epithelial tumors (TETs) has been investigated for inclusion in future staging systems, but large cohort results still are missing. This study aimed to analyze the prognostic role of NIS for patients included in the European Society of Thoracic Surgeons (ESTS) thymic database who underwent surgical resection.

methodsClinical and pathologic data of patients from the ESTS thymic database who underwent surgery for TET from January 2000 to July 2019 with infiltration of surrounding structures were reviewed and analyzed. Patients' clinical data, tumor characteristics, and NIS were collected and correlated with CSS using Kaplan-Meier curves. The log-rank test was used to assess differences between subgroups. A multivariable model was built using logistic regression analysis.

resultsThe final analysis was performed on 303 patients. Histology showed thymoma for 216 patients (71.3%) and NET/thymic carcinoma [TC]) for 87 patients (28.7%). The most frequently infiltrated structures were the pleura (198 cases, 65.3%) and the pericardium in (185 cases, 61.1%), whereas lung was involved in 96 cases (31.7%), great vessels in 74 cases (24.4%), and the phrenic nerve in 31 cases (10.2%). Multiple structures (range, 2-7) were involved in 183 cases (60.4%). Recurrence resulted in the death of 46 patients. The CSS mortality rate was 89% at 5 years and 82% at 10 years. In the univariable analysis, the favorable prognostic factors were neoadjuvant therapy, Masaoka stage 3, absence of metastases, absence of myasthenia gravis, complete resection, thymoma histology, and no more than two NIS. Patients with more than two NIS presented with a significantly worse CSS than patients with no more than two NIS (CSS 5- and 10-year rates: 9.5% and 83.5% vs 93.2% and 91.2%, respectively; p = 0.04). The negative independent prognostic factors confirmed by the multivariable analysis were incomplete resection (hazard ratio [HR] 2.543; 95% confidence interval [CI] 1.010-6.407; p = 0.048) and more than two NIS (HR 1.395; 95% CI 1.021-1.905; p = 0.036).

conclusionsThe study showed that more than two involved structures are a negative independent prognostic factor in infiltrative thymic epithelial tumors that could be used for prognostic stratification.

Indexed as

Databases, FactualNeoplasms, Glandular and EpithelialThymus NeoplasmsAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPleuraPrognosisRetrospective StudiesSurvival RateInfiltrationStagingThymic carcinomaThymoma

Identifiers

PMID38530530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.