Evidence map›Paper›PMID 38530413›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2024

Risk factors associated with in-hospital complications for pediatric sickle-cell disease-associated moyamoya syndrome: a nationwide cross-sectional study.

Robert C Osorio, Kunal P Raygor, Lorenzo Rinaldo, Christine K Fox, Neha Bhasin, Adib A Abla, Nalin Gupta

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Robert C OsorioDepartment of Neurological Surgery, University of California San Francisco, 550 16th Street, 5th Floor, San Francisco, CA, USA.
Kunal P RaygorDepartment of Neurological Surgery, University of California San Francisco, 550 16th Street, 5th Floor, San Francisco, CA, USA.
Lorenzo RinaldoDepartment of Neurological Surgery, University of California San Francisco, 550 16th Street, 5th Floor, San Francisco, CA, USA.
Christine K FoxDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Neha BhasinDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Adib A AblaDepartment of Neurological Surgery, University of California San Francisco, 550 16th Street, 5th Floor, San Francisco, CA, USA.
Nalin GuptaDepartment of Neurological Surgery, University of California San Francisco, 550 16th Street, 5th Floor, San Francisco, CA, USA. nalin.gupta@ucsf.edu.
University of California, San Francisco · USNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSickle-cell disease-associated moyamoya syndrome (SCD-MMS) carries a high risk for recurrent strokes and cerebrovascular morbidity in children. However, few data are available about complications that occur in children hospitalized with SCD-MMS. The purpose of this analysis was to determine the risk factors for in-hospital complications in pediatric SCD-MMS admissions, and thus aid physicians in optimizing future treatment plans.

methodsA national database of pediatric hospital admissions was examined across the years 2003-2019. ICD-9 and ICD-10 diagnosis codes were analyzed to identify discharges with a primary diagnosis of SCD-MMS and identify in-hospital complications, defined as complication-associated diagnostic codes logged during the same admission. Patient demographics, comorbidities, and hospital characteristics were examined using univariate and multivariate logistic regression analyses to determine associations with in-hospital complications.

resultsIn total, 274 admissions with a primary diagnosis of SCD-MMS were identified. During 64 (23.4%) admissions, transfusion therapy was given, and in 86 admissions (31.4%), surgical revascularization was performed. In 10 admissions (3.6%), a total of 11 in-hospital complications were identified. After multivariate regression, both comorbid chronic lung disease (adjusted OR 5.3 [1.1, 26.9], P = 0.04) and surgical revascularization (adjusted OR 10.2 [2.0, 52.4], P = 0.006) were associated with development of complications.

conclusionsIn this nationwide database of pediatric SCD-MMS hospitalizations, comorbid chronic lung disease and surgical revascularization were associated with development of in-hospital complications. Patients with comorbid chronic lung disease or who are admitted for revascularization may warrant closer monitoring and greater medical optimization during the hospitalization.

Indexed as

Anemia, Sickle CellMoyamoya DiseaseAdolescentChildChild, PreschoolCross-Sectional StudiesDatabases, FactualFemaleHospitalizationHumansInfantMaleRisk FactorsComplicationsMoyamoya syndromePediatricsSickle-cell disease

Identifiers

PMID38530413
OpenAlexW4393200580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.