Evidence map›Paper›PMID 38530252›Full record

ArticleThe Journal of cell biology2024

Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains.

Yang E Li, Dougall M Norris, Fanqian N Xiao, Elvis Pandzic, Renee M Whan, Sandra Fok, Ming Zhou, Guangwei Du, Yang Liu, Ximing Du and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Lysosomal Repair in Health and Disease.Journal of cellular physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Yang E Li *School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0009-0000-4459-8014
Dougall M Norris *School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0000-0001-8201-4999
Fanqian N XiaoSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0009-0000-0718-1375
Elvis PandzicKaterina Gaus Light Microscopy Facility, Mark Wainwright Analytical Center, University of New South Wales, Sydney, Australia.ORCID 0000-0003-3733-0890
Renee M WhanKaterina Gaus Light Microscopy Facility, Mark Wainwright Analytical Center, University of New South Wales, Sydney, Australia.ORCID 0000-0002-6664-6344
Sandra FokKaterina Gaus Light Microscopy Facility, Mark Wainwright Analytical Center, University of New South Wales, Sydney, Australia.ORCID 0000-0001-8509-4613
Ming ZhouVerna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-7198-165X
Guangwei DuDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-4193-6975
Yang LiuDepartment of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-4428-3562
Ximing DuSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0000-0002-6648-017X
Hongyuan YangSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia.ORCID 0000-0002-8482-6031
UNSW Sydney · AUThe University of Texas Health Science Center at Houston · USBaylor College of Medicine · US

Funding

National Health and Medical Research Council 1141938University of New South WalesUniversity of Texas Health Science Center at Houston
6 · The paper itself

Abstract

The integrity of the plasma membrane is critical to cell function and survival. Cells have developed multiple mechanisms to repair damaged plasma membranes. A key process during plasma membrane repair is to limit the size of the damage, which is facilitated by the presence of tetraspanin-enriched rings surrounding damage sites. Here, we identify phosphatidylserine-enriched rings surrounding damaged sites of the plasma membrane, resembling tetraspanin-enriched rings. Importantly, the formation of both the phosphatidylserine- and tetraspanin-enriched rings requires phosphatidylserine and its transfer proteins ORP5 and ORP9. Interestingly, ORP9, but not ORP5, is recruited to the damage sites, suggesting cells acquire phosphatidylserine from multiple sources upon plasma membrane damage. We further demonstrate that ORP9 contributes to efficient plasma membrane repair. Our results thus unveil a role for phosphatidylserine and its transfer proteins in facilitating the formation of tetraspanin-enriched macrodomains and plasma membrane repair.

Indexed as

Cell MembranePhosphatidylserinesTetraspaninsHeLa CellsHumansMembrane ProteinsOxysterol Binding ProteinsReceptors, SteroidMembrane ProteinsOxysterol Binding ProteinsPhosphatidylserinesReceptors, SteroidTetraspanins

Identifiers

PMID38530252
PMCPMC10964951
OpenAlexW4393191430

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.