Evidence map›Paper›PMID 38530033›Full record

ArticlemBio2024

Altered PBP4 and GdpP functions synergistically mediate MRSA-like high-level, broad-spectrum β-lactam resistance in

Li-Yin Lai, Nidhi Satishkumar, Sasha Cardozo, Vijay Hemmadi, Leonor B Marques, Liusheng Huang, Sergio R Filipe, Mariana G Pinho, Henry F Chambers, Som S Chatterjee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Mislocalization of PBPs inMicrobiology spectrum · 2026
    Article
  3. Review
  4. Co-occurrence of blaBMC microbiology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Li-Yin Lai *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA.
Nidhi Satishkumar *Department of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA.ORCID 0000-0003-1290-1159
Sasha CardozoDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA.
Vijay HemmadiDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA.
Leonor B MarquesInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Liusheng HuangDepartment of Clinical Pharmacy, Drug Research Unit, University of California, San Francisco, California, USA.ORCID 0000-0003-2702-4486
Sergio R FilipeInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.
Mariana G PinhoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Oeiras, Portugal.ORCID 0000-0002-7132-8842
Henry F ChambersDivision of Infectious Diseases, School of Medicine, University of California San Francisco, San Francisco, California, USA.
Som S ChatterjeeDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland Baltimore, Baltimore, Maryland, USA.ORCID 0000-0002-7138-4449
University of Maryland, Baltimore · USUniversidade Nova de Lisboa · PTUniversity of California, San Francisco · USRede de Química e Tecnologia · PT

Funding

Novel Mechanisms of Beta-lactam Resistance in Staph AureusR01AI100291 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI CHATTERJEE, SOM, HENRY CHAMBERS, HENRY F · 2013 to 2023
$5.1M
Serine/threonine kinase signaling in beta-lactam resistance of Staphylococcus aureusR01AI165510 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Som Chatterjee · 2023 to 2026
$2.8M
NIAID NIH HHS R01 AI100291NIAID NIH HHS R01 AI165510
6 · The paper itself

Abstract

Infections caused by IMPORTANCE: In

Indexed as

Anti-Bacterial Agentsbeta-Lactam Resistancebeta-LactamsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPenicillin-Binding ProteinsBacterial ProteinsHumansMutationPhosphoric Diester HydrolasesStaphylococcal InfectionsStaphylococcus aureusAnti-Bacterial AgentsBacterial Proteinsbeta-LactamsmecA protein, Staphylococcus aureusPenicillin-Binding ProteinsPhosphoric Diester HydrolasesSAOUHSC_00015 protein, Staphylococcus aureusSAOUHSC_00646 protein, Staphylococcus aureusgdpPmethicillin-resistant lacking mec (MRLM)pbp4β-lactam resistance

Identifiers

PMID38530033
PMCPMC11077961
OpenAlexW4393191705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.