Evidence map›Paper›PMID 38529957›Full record

Observational studyInflammatory bowel diseases2025

Pan-enteric Capsule Endoscopy to Characterize Crohn's Disease Phenotypes and Predict Clinical Outcomes in Children and Adults: The Bomiro Study.

Salvatore Oliva, Silvio Veraldi, Giusy Russo, Marina Aloi, Fernando Rizzello, Paolo Gionchetti, Patrizia Alvisi, Flavio Labriola, Maurizio Vecchi, Pini Eidler and 4 more

Open access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Inflammatory bowel diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. New Technologies for IBD Endoscopy.Journal of clinical medicine · 2026
    Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Salvatore OlivaPediatric Gastroenterology and Liver Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.ORCID 0000-0003-2348-2308
Silvio VeraldiPediatric Gastroenterology and Liver Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Giusy RussoPediatric Gastroenterology and Liver Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Marina AloiPediatric Gastroenterology and Liver Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Fernando RizzelloIBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy.
Paolo GionchettiIBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy.
Patrizia AlvisiPediatric Gastroenterology Unit, Maggiore Hospital, Largo Bartolo Nigrisoli, 2, 40133 Bologna, Italy.ORCID 0000-0003-2770-1379
Flavio LabriolaPediatric Gastroenterology Unit, Maggiore Hospital, Largo Bartolo Nigrisoli, 2, 40133 Bologna, Italy.
Maurizio VecchiDepartment of Pathophysiology and Transplantation, University of Milan, Italy.ORCID 0000-0003-1558-8604
Pini EidlerDivision of Gastroenterology and Endoscopy, Foundation IRCCS Ca' Granda Ospedale Maggiore.
Luca ElliDivision of Gastroenterology and Endoscopy, Foundation IRCCS Ca' Granda Ospedale Maggiore.
Nikolas DussiasIBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy.
Gian Eugenio TontiniDepartment of Pathophysiology and Transplantation, University of Milan, Italy.
Carlo CalabreseIBD Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy.ORCID 0000-0003-3657-4463
Azienda USL di Bologna · ITSapienza University of Rome · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale Maggiore · ITUniversity of Milan · ITBambino Gesù Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn's disease (CD), especially in children. No study has evaluated the ability of PCE to characterize CD phenotypes and outcomes in children and adults.

methodsIn a prospective multicenter observational study, we recruited patients with CD >6 years from 4 centers in Italy. Patients underwent clinical, biomarker assessment and PCE. Lesions were graded using the PCE system. For each segment, the most common lesion (MCL), the most severe lesion (MSL), and the extent of involvement were defined. Disease severity, extent, and clinical outcomes were compared between children and adults. A logistic regression analysis was used to identify predictive factors for negative outcomes in both age groups.

resultsOne hundred ninety-four consecutive patients (adults/children: 144/50) were evaluated for a total of 249 procedures. Children were more likely to have extensive disease, particularly in the colon. Higher MCL scores were independently associated with treatment escalation (odds ratio [OR], 4.09; 95% CI, 1.80-9.25; P = .001), while >30% disease extent was more indicative of clinical and endoscopic relapse (OR, 2.98; 1.26-7.08; P = .013). Disease extent was the only factor associated with endoscopic recurrence in children (OR, 4.50; 95% CI, 1.47-13.77; P = .008), while severe lesions in adults provided a better predictor of treatment escalation (OR, 4.31; 95% CI, 1.52-12.1; P = .006). Postexamination, PCE contributed to a change of therapy in 196/249 (79%) of the procedures.

conclusionsPCE allowed the characterization of CD phenotypes in children and adults by assessing disease severity and extent, which are of different importance in predicting clinical outcomes in these age groups.

Indexed as

Capsule EndoscopyCrohn DiseaseAdolescentAdultChildFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedPhenotypePrognosisProspective StudiesSeverity of Illness IndexYoung Adultintestinal inflammationmonitoringnoninvasive endoscopypan-enteric capsule

Identifiers

PMID38529957
PMCPMC12628309
OpenAlexW4393181807

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.