Evidence map›Paper›PMID 38529790›Full record

ArticleChemical communications (Cambridge, England)2024

An organometallic swap strategy for bottlebrush polymer-protein conjugate synthesis.

Bin Liu, Jacob Rodriguez, Landon J Kilgallon, Wencong Wang, Yuyan Wang, Aiden Wang, Yutong Dai, Hung V-T Nguyen, Bradley L Pentelute, Jeremiah A Johnson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Bin LiuDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0003-1736-9392
Jacob RodriguezDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0003-1202-5013
Landon J KilgallonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0009-0003-1637-7523
Wencong WangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0001-9578-209X
Yuyan WangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.
Aiden WangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0001-6335-9836
Yutong DaiDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.
Hung V-T NguyenDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0002-6945-4057
Bradley L PenteluteDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0002-7242-801X
Jeremiah A JohnsonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA. jaj2109@mit.edu.ORCID http://orcid.org/0000-0001-9157-6491
Massachusetts Institute of Technology · USBroad Institute · US

Funding

Organic nanoparticles for dual MRI-guided therapeutic selection and ovarian cancer drug deliveryR01CA220468 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jeremiah Allen Johnson · 2017 to 2026
$4.9M
NCI NIH HHS R01 CA220468
6 · The paper itself

Abstract

Polymer-protein bioconjugation offers a powerful strategy to alter the physical properties of proteins, and various synthetic polymer compositions and architectures have been investigated for this purpose. Nevertheless, conjugation of molecular bottlebrush polymers (BPs) to proteins remains an unsolved challenge due to the large size of BPs and a general lack of methods to transform the chain ends of BPs into functional groups suitable for bioconjugation. Here, we present a strategy to address this challenge in the context of BPs prepared by "graft-through" ring-opening metathesis polymerization (ROMP), one of the most powerful methods for BP synthesis. Quenching ROMP of PEGylated norbornene macromonomers with an activated enyne terminator facilitates the transformation of the BP Ru alkylidene chain ends into Pd oxidative addition complexes (OACs) for facile bioconjugation. This strategy is shown to be effective for the synthesis of two BP-protein conjugates (albumin and ERG), setting the stage for a new class of BP-protein conjugates for future therapeutic and imaging applications.

Indexed as

PolymersProteinsAlbuminsPolymerizationAlbuminsPolymersProteins

Identifiers

PMID38529790
PMCPMC11008127
OpenAlexW4392969806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.