Evidence map›Paper›PMID 38529720›Full record

ArticleHistology and histopathology2024

Upregulation and epigenetic modification of the creatine transporter SLC6A8 in non-small cell lung cancer.

Christiane Kuempers, Karoline Schnepf, Sebastian Marwitz, Christian Watermann, Andreas H Scheel, Rieke N Fischer, Ole Ammerpohl, Sven Perner, Daniel Drömann, Torsten Goldmann

Abstract read
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In one paragraph

Article in Histology and histopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christiane Kuempers *Institute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. christiane.kuempers@uksh.de.
Karoline Schnepf *Medical Clinic III, Pulmonology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Sebastian MarwitzAirway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
Christian WatermannInstitute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
Andreas H ScheelInstitute of Pathology, University Hospital of Cologne, University of Cologne, Cologne, Germany.
Rieke N FischerLung Cancer Group Cologne, Department I for Internal Medicine and Center for Integrated Oncology Aachen Bonn Cologne Dusseldorf, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Ole AmmerpohlAirway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
Sven PernerInstitute for Hematopathology Hamburg, Hamburg, Germany.
Daniel Drömann *Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
Torsten Goldmann *Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Großhansdorf, Germany.
German Center for Lung Research · DEInstitut für Hämatopathologie Hamburg · DEUniversity Hospital Cologne · DEUniversity Hospital Schleswig-Holstein · DE

Funding

German Center for Lung Research 82DZL001A5German Ministry for Education and Research 01EY1103
6 · The paper itself

Abstract

introductionLung cancer is a major cause of cancer-related death worldwide and effective therapies, besides surgery, are available only for a small proportion of patients. Since cellular respiration is known to be broadly altered in malignant tumors, the cellular processes of respiration can be a potential therapeutic target. One important element of cellular respiration is creatine and its transport by the creatine transporter SLC6A8. Here we describe the expression of SLC6A8 at the RNA and protein level, epigenetic modifications as well as survival analysis in NSCLC tissues and matched controls. MATERIALS AND

methodsWe analyzed epigenetic modifications of the

results

conclusionsOur results suggest an important role of creatine and its transport via SLC6A8 in NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungEpigenesis, GeneticLung NeoplasmsUp-RegulationAdultAgedBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsBiomarkers, Tumorcreatine transporterMembrane Transport ProteinsNerve Tissue ProteinsPlasma Membrane Neurotransmitter Transport ProteinsSLC6A8 protein, human

Identifiers

PMID38529720
OpenAlexW4394745077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.