Evidence map›Paper›PMID 38529532›Full record

ArticleeLife2024

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment.

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori and 121 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

131 authors at 20 institutions in 12 countries.

Hideo HagiharaDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.ORCID https://orcid.org/0000-0001-9602-9518
Hirotaka ShojiDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.
Satoko HattoriDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.
Giovanni SalaDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.
Yoshihiro TakamiyaDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.
Mika TanakaDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.
Masafumi IharaDepartment of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Mihiro ShibutaniLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Izuho HatadaLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Kei HoriDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Mikio HoshinoDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID https://orcid.org/0000-0002-9526-3473
Akito NakaoDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-2296-8245
Yasuo MoriDepartment of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Shigeo OkabeDepartment of Cellular Neurobiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1216-8890
Masayuki MatsushitaDepartment of Molecular Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.
Anja UrbachDepartment of Neurology, Jena University Hospital, Jena, Germany.
Yuta KatayamaDepartment of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Akinobu MatsumotoDepartment of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Keiichi I NakayamaDepartment of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Shota KatoriLaboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Japan.
Takuya SatoLaboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Japan.
Takuji IwasatoLaboratory of Mammalian Neural Circuits, National Institute of Genetics, Mishima, Japan.
Haruko NakamuraDepartment of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yoshio GoshimaDepartment of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Matthieu RaveauLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Japan.
Tetsuya TatsukawaLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Japan.
Kazuhiro YamakawaLaboratory for Neurogenetics, RIKEN Center for Brain Science, Wako, Japan.ORCID https://orcid.org/0000-0002-1478-4390
Noriko TakahashiLaboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Haruo KasaiLaboratory of Structural Physiology, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2327-9027
Johji InazawaResearch Core, Tokyo Medical and Dental University, Tokyo, Japan.
Ikuo NobuhisaDepartment of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Tetsushi KagawaDepartment of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Tetsuya TagaDepartment of Stem Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Mohamed DarwishDepartment of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Hirofumi NishizonoMedical Research Institute, Kanazawa Medical University, Kahoku, Japan.
Keizo TakaoDepartment of Behavioral Physiology, Graduate School of Innovative Life Science, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0002-4734-3583
Kiran SapkotaDepartment of Neuroscience, Southern Research, Birmingham, United States.
Kazutoshi NakazawaDepartment of Neuroscience, Southern Research, Birmingham, United States.
Tsuyoshi TakagiInstitute for Developmental Research, Aichi Developmental Disability Center, Kasugai, Japan.
Haruki FujisawaDepartment of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University, Toyoake, Japan.
Yoshihisa SugimuraDepartment of Endocrinology, Diabetes and Metabolism, School of Medicine, Fujita Health University, Toyoake, Japan.
Kyosuke YamanishiDepartment of Neuropsychiatry, Hyogo Medical University School of Medicine, Nishinomiya, Japan.ORCID https://orcid.org/0000-0001-5130-8193
Lakshmi RajagopalDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States.
Nanette Deneen HannahDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States.
Herbert Y MeltzerDepartment of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, United States.
Tohru YamamotoDepartment of Molecular Neurobiology, Faculty of Medicine, Kagawa University, Kita-gun, Japan.ORCID https://orcid.org/0000-0002-1652-0233
Shuji WakatsukiDepartment of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Toshiyuki ArakiDepartment of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Katsuhiko TabuchiDepartment of Molecular & Cellular Physiology, Shinshu University School of Medicine, Matsumoto, Japan.
Tadahiro NumakawaDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Hiroshi KunugiDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Freesia L HuangProgram of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, United States.
Atsuko Hayata-TakanoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Hitoshi HashimotoLaboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.ORCID https://orcid.org/0000-0001-6548-4016
Kota TamadaRIKEN Brain Science Institute, Wako, Japan.ORCID https://orcid.org/0000-0002-6575-6189
Toru TakumiRIKEN Brain Science Institute, Wako, Japan.ORCID https://orcid.org/0000-0001-7153-266X
Takaoki KasaharaLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako, Japan.ORCID https://orcid.org/0000-0002-0953-5146
Tadafumi KatoLaboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako, Japan.
Isabella A GraefDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Gerald R CrabtreeDepartment of Pathology, Stanford University School of Medicine, Stanford, United States.
Nozomi AsaokaDepartment of Pharmacology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hikari HatakamaDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Shuji KanekoDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Takao KohnoDepartment of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.ORCID https://orcid.org/0000-0003-2557-4281
Mitsuharu HattoriDepartment of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan.
Yoshio HoshibaLaboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Ryuhei MiyakeLaboratory for Multi-scale Biological Psychiatry, RIKEN Center for Brain Science, Wako, Japan.
Kisho Obi-NagataLaboratory for Multi-scale Biological Psychiatry, RIKEN Center for Brain Science, Wako, Japan.
Akiko Hayashi-TakagiLaboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Léa J BeckerInstitut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, France.
Ipek YalcinInstitut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Université de Strasbourg, Strasbourg, France.
Yoko HaginoAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hiroko Kotajima-MurakamiAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Yuki MoriyaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Kazutaka IkedaAddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hyopil KimDepartment of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Bong-Kiun KaangDepartment of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0001-7593-9707
Hikari OtabiCollege of Agriculture, Ibaraki University, Ami, Japan.
Yuta YoshidaCollege of Agriculture, Ibaraki University, Ami, Japan.
Atsushi ToyodaCollege of Agriculture, Ibaraki University, Ami, Japan.
Noboru H KomiyamaGenes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Seth G N GrantGenes to Cognition Program, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0001-8732-8735
Michiru Ida-EtoDepartment of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, Tsu, Japan.
Masaaki NaritaDepartment of Developmental and Regenerative Medicine, Mie University, Graduate School of Medicine, Tsu, Japan.
Ken-Ichi MatsumotoDepartment of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, Japan.
Emiko Okuda-AshitakaDepartment of Biomedical Engineering, Osaka Institute of Technology, Osaka, Japan.
Iori OhmoriDepartment of Physiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Tadayuki ShimadaChild Brain Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7333-9847
Kanato YamagataChild Brain Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Hiroshi AgetaDivision for Therapies Against Intractable Diseases, Center for Medical Science, Fujita Health University, Toyoake, Japan.
Kunihiro TsuchidaDivision for Therapies Against Intractable Diseases, Center for Medical Science, Fujita Health University, Toyoake, Japan.ORCID https://orcid.org/0000-0002-3983-5756
Kaoru InokuchiResearch Center for Idling Brain Science, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0002-5393-3133
Takayuki SassaFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.ORCID https://orcid.org/0000-0003-3145-9829
Akio KiharaFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.ORCID https://orcid.org/0000-0001-5889-0788
Motoaki FukasawaDepartment of Anatomy II, Fujita Health University School of Medicine, Toyoake, Japan.
Nobuteru UsudaDepartment of Anatomy II, Fujita Health University School of Medicine, Toyoake, Japan.
Tayo KatanoDepartment of Medical Chemistry, Kansai Medical University, Hirakata, Japan.
Teruyuki TanakaDepartment of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yoshihiro YoshiharaLaboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Wako, Japan.
Michihiro IgarashiDepartment of Neurochemistry and Molecular Cell Biology, School of Medicine, and Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0003-1474-3385
Takashi HayashiBiomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.ORCID https://orcid.org/0000-0003-3591-2109
Kaori IshikawaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.ORCID https://orcid.org/0000-0001-9895-5996
Satoshi YamamotoIntegrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa, Japan.
Naoya NishimuraIntegrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company, Ltd, Fujisawa, Japan.
Kazuto NakadaInstitute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan.
Shinji HirotsuneDepartment of Genetic Disease Research, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kiyoshi EgawaDepartment of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Kazuma HigashisakaLaboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Yasuo TsutsumiLaboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Shoko NishiharaGlycan & Life Systems Integration Center (GaLSIC), Soka University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-1668-2603
Noriyuki SugoGraduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Takeshi YagiGraduate School of Frontier Biosciences, Osaka University, Suita, Japan.
Naoto UenoLaboratory of Morphogenesis, National Institute for Basic Biology, Okazaki, Japan.ORCID https://orcid.org/0000-0002-8375-2317
Tomomi YamamotoDivision of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Japan.
Yoshihiro KuboDivision of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Japan.ORCID https://orcid.org/0000-0001-6707-0837
Rie OhashiLaboratory of Neuronal Cell Biology, National Institute for Basic Biology, Okazaki, Japan.
Nobuyuki ShiinaLaboratory of Neuronal Cell Biology, National Institute for Basic Biology, Okazaki, Japan.ORCID https://orcid.org/0000-0002-1854-4239
Kimiko ShimizuDepartment of Biological Sciences, School of Science, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4943-2552
Sayaka Higo-YamamotoHealthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Katsutaka OishiHealthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.ORCID https://orcid.org/0000-0002-4870-0837
Hisashi MoriDepartment of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.ORCID https://orcid.org/0000-0001-9743-2456
Tamio FuruseMouse Phenotype Analysis Division, Japan Mouse Clinic, RIKEN BioResource Research Center (BRC), Tsukuba, Japan.
Masaru TamuraMouse Phenotype Analysis Division, Japan Mouse Clinic, RIKEN BioResource Research Center (BRC), Tsukuba, Japan.
Hisashi ShirakawaDepartment of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.ORCID https://orcid.org/0000-0002-4129-0978
Daiki X SatoDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.ORCID https://orcid.org/0000-0002-9527-8253
Yukiko U InoueDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.ORCID https://orcid.org/0000-0002-4105-9127
Takayoshi InoueDepartment of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan.
Yuriko KomineYoung Researcher Support Group, Research Enhancement Strategy Office, National Institute for Basic Biology, National Institute of Natural Sciences, Okazaki, Japan.ORCID https://orcid.org/0000-0002-0097-8813
Tetsuo YamamoriDivision of Brain Biology, National Institute for Basic Biology, Okazaki, Japan.
Kenji SakimuraDepartment of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Japan.ORCID https://orcid.org/0000-0002-8091-8879
Tsuyoshi MiyakawaDivision of Systems Medical Science, Center for Medical Science, Fujita Health University, Toyoake, Japan.ORCID https://orcid.org/0000-0003-0137-8200
Fujita Health University · JPRIKEN Center for Brain Science · JPNational Center of Neurology and Psychiatry · JPTokyo Metropolitan Institute of Medical Science · JPKyoto University · JPNational Institute for Basic Biology · JPGunma University · JPThe University of Tokyo · JPTokyo Medical and Dental University · JPHokkaido University · JPIbaraki University · JPKyushu University · JPNational Institute of Genetics · JPNorthwestern University · USUniversity of Tsukuba · JPCentre National pour la Recherche Scientifique et Technique (CNRST) · MAKagawa University · JPKanazawa University · JPMie University · JPMRC Cognition and Brain Sciences Unit · GB

Funding

ATP-Dependent Chromatin Remodeling in Human MalignancyR01CA163915 · NCI · STANFORD UNIVERSITY · PI Gerald R. Crabtree · 2012 to 2026
$5.4M
Signaling by Calcineurin and NFAT in Axonal OutgrowthR01NS046789 · NINDS · STANFORD UNIVERSITY · PI CRABTREE, GERALD R. · 2003 to 2012
$3.4M
HIJACKING CANCER DRIVERS TO ACTIVATE PROAPOPTOTIC GENES IN DLBCLR01CA276167 · NCI · STANFORD UNIVERSITY · PI Gerald R. Crabtree, NATHANAEL Schiander GRAY · 2023 to 2026
$2.2M
Small molecule regulation of endogenous transcription factors for circuit-specific neuromodulationRF1MH126720 · NIMH · STANFORD UNIVERSITY · PI CRABTREE, GERALD R. · 2021 to 2021
$1.3M
Japan Agency for Medical Research and Development JP18dm0107101Japan Society for the Promotion of Science JP16H06276Japan Society for the Promotion of Science JP18K07378Japan Society for the Promotion of Science JP20H00522Japan Society for the Promotion of Science JP21K19314Ministry of Education, Culture, Sports, Science and Technology JP16H06462Ministry of Education, Culture, Sports, Science and Technology JPMXP0618217663NCI NIH HHS R01 CA163915NCI NIH HHS R01 CA276167NIMH NIH HHS RF1 MH126720NINDS NIH HHS R01 NS046789
6 · The paper itself

Abstract

Increased levels of lactate, an end-product of glycolysis, have been proposed as a potential surrogate marker for metabolic changes during neuronal excitation. These changes in lactate levels can result in decreased brain pH, which has been implicated in patients with various neuropsychiatric disorders. We previously demonstrated that such alterations are commonly observed in five mouse models of schizophrenia, bipolar disorder, and autism, suggesting a shared endophenotype among these disorders rather than mere artifacts due to medications or agonal state. However, there is still limited research on this phenomenon in animal models, leaving its generality across other disease animal models uncertain. Moreover, the association between changes in brain lactate levels and specific behavioral abnormalities remains unclear. To address these gaps, the International Brain pH Project Consortium investigated brain pH and lactate levels in 109 strains/conditions of 2294 animals with genetic and other experimental manipulations relevant to neuropsychiatric disorders. Systematic analysis revealed that decreased brain pH and increased lactate levels were common features observed in multiple models of depression, epilepsy, Alzheimer's disease, and some additional schizophrenia models. While certain autism models also exhibited decreased pH and increased lactate levels, others showed the opposite pattern, potentially reflecting subpopulations within the autism spectrum. Furthermore, utilizing large-scale behavioral test battery, a multivariate cross-validated prediction analysis demonstrated that poor working memory performance was predominantly associated with increased brain lactate levels. Importantly, this association was confirmed in an independent cohort of animal models. Collectively, these findings suggest that altered brain pH and lactate levels, which could be attributed to dysregulated excitation/inhibition balance, may serve as transdiagnostic endophenotypes of debilitating neuropsychiatric disorders characterized by cognitive impairment, irrespective of their beneficial or detrimental nature.

Indexed as

Cognitive DysfunctionEndophenotypesAnimalsBrainDisease Models, AnimalHumansHydrogen-Ion ConcentrationLactatesMiceLactatesanimal modelsbrain pHchickenlactatemetabolismmouseneuropsychiatric disordersneuroscienceratworking memory

Identifiers

PMID38529532
PMCPMC10965225
OpenAlexW4386368880

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.