Evidence map›Paper›PMID 38529506›Full record

ArticlebioRxiv : the preprint server for biology2024

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness.

Onur Eskiocak, Saria Chowdhury, Vyom Shah, Emmanuella Nnuji-John, Charlie Chung, Jacob A Boyer, Alexander S Harris, Jill Habel, Michel Sadelain, Semir Beyaz and 1 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Onur EskiocakCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Saria ChowdhuryCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Vyom ShahCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Emmanuella Nnuji-JohnCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Charlie ChungCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Jacob A BoyerLewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University; Princeton, NJ, USA.
Alexander S HarrisCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Jill HabelCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Michel SadelainCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Semir BeyazCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Corina AmorCold Spring Harbor Laboratory; Cold Spring Harbor, NY, USA.
Cold Spring Harbor Laboratory · USMemorial Sloan Kettering Cancer Center · USPrinceton University · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Deconstructing aging with senolytic CAR T cellsDP5OD033055 · OD · COLD SPRING HARBOR LABORATORY · PI AMOR VEGAS, CORINA · 2022 to 2025
$2.4M
Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of agingR01AG082800 · NIA · COLD SPRING HARBOR LABORATORY · PI Corina Amor Vegas · 2023 to 2026
$2.1M
NCI NIH HHS P30 CA045508NIA NIH HHS R01 AG082800NIH HHS DP5 OD033055
6 · The paper itself

Abstract

Intestinal stem cells (ISCs) drive the rapid regeneration of the gut epithelium to maintain organismal homeostasis. Aging, however, significantly reduces intestinal regenerative capacity. While cellular senescence is a key feature of the aging process, little is known about the

Identifiers

PMID38529506
PMCPMC10962734
OpenAlexW4393064984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.