Evidence map›Paper›PMID 38529501›Full record

ArticlebioRxiv : the preprint server for biology2024

Comparative study of enriched dopaminergic neurons from siblings with Gaucher disease discordant for parkinsonism.

Ellen Hertz, Gani Perez, Ying Hao, Krystyna Rytel, Charis Ma, Martha Kirby, Stacie Anderson, Stephen Wincovitch, Kate Andersh, Tim Ahfeldt and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Ellen HertzMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Gani PerezMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Ying HaoCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Krystyna RytelMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Charis MaMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Martha KirbyNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Stacie AndersonNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Stephen WincovitchNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Kate AndershCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Tim AhfeldtNash Family Department of Neuroscience at Mount Sinai, New York, NY, USA.
Joel BlanchardNash Family Department of Neuroscience at Mount Sinai, New York, NY, USA.
Yue Andy QiCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Grisel LopezMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Nahid TayebiMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Ellen SidranskyMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.
Yu ChenMedical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-5438-7309
National Institutes of Health · USResearch Network (United States) · US

Funding

Genetic and clinical studies of Gaucher disease and other lysosomal disordersZIAHG200336 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI SIDRANSKY, ELLEN · 2009 to 2025
$45.2M
6 · The paper itself

Abstract

Inducible pluripotent stem cells (iPSCs) derived from patient samples have significantly enhanced our ability to model neurological diseases. Comparative studies of dopaminergic (DA) neurons differentiated from iPSCs derived from siblings with Gaucher disease discordant for parkinsonism provides a valuable avenue to explore genetic modifiers contributing to

Indexed as

dopaminergic neuron differentiationGaucher diseaseGBA1iPSCneomycin resistanceneurodegenerationParkinson disease

Identifiers

PMID38529501
PMCPMC10962709
OpenAlexW4392243974

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.