ArticleJournal of oral microbiology2024
Oral and gut microbial profiling in periodontitis and Parkinson's disease.
Article in Journal of oral microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Aging and periodontitis increase brain dissemination of oral bacteria.Journal of periodontology · 2026Article
- Analysis of salivary metabolites and microbial characteristics in patients with dental fluorosis.Clinical oral investigations · 2026Article
- DNA framework-based nanomedicine platform: a triple-function strategy for treating periodontitis via antibacterial, anti-inflammatory, and osteogenesis-promoting activities.International journal of oral science · 2026Article
- From dysbiosis to cellular invasion: reassessing the pathogenic role of parvimonas micra in periodontitis as an understudied pathobiont.EBioMedicine · 2026Article
- Periodontal inflammation and tryptophan-kynurenine metabolism in Parkinson's disease.Clinical oral investigations · 2026Article
- Integrative meta-analysis of the OSCC microbiome: from niche-specific heterogeneity to universal network and functional signatures.Journal of oral microbiology · 2026Article
- Alterations in gut microbiota and plasma metabolites in pulmonary arterial hypertension secondary to congenital left-to-right shunt heart disease: potential mechanisms and biomarkers.Frontiers in genetics · 2026Article
- Comparative Study of Patients with Periodontal and Parkinson's Disease: Clinical and Salivary Aspects.Biomedicines · 2025Article
- SANA-Biome: A Protocol for a Cross-Sectional Study on Oral Health, Diet, and the Oral Microbiome in Romania.Healthcare (Basel, Switzerland) · 2025Article
- Oral health implications in Parkinson's disease.NPJ Parkinson's disease · 2025Review
- Altered oral health and microbiota in drug-free patients with schizophrenia.BMC psychiatry · 2025Observational
- Correlations Between Amelioration of Rotenone-Induced Parkinson's Symptoms byInternational journal of molecular sciences · 2025Article
- Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Specific gut microbiota and serum metabolite changes in patients with osteoarthritis.Frontiers in cell and developmental biology · 2025Article
- Microbiota Orchestra in Parkinson's Disease: The Nasal and Oral Maestros.Biomedicines · 2024Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Objectives: We tested the hypothesis that Parkinson's disease (PA) alters the periodontitis-associated oral microbiome. Method: Patients with periodontitis with Parkinson's disease (PA+P) and without PA (P) and systemically and periodontally healthy individuals (HC) were enrolled. Clinical, periodontal and neurological parameters were recorded. The severity of PA motor functions was measured. Unstimulated saliva samples and stool samples were collected. Next-generation sequencing of 16S ribosomal RNA (V1-V3 regions) was performed. Results: PA patients had mild-to-moderate motor dysfunction and comparable plaque scores as those without, indicating that oral hygiene was efficient in the PA+P group. In saliva, there were statistically significant differences in beta diversity between HC and PA+P (p = 0.001), HC and P (p = 0.001), and P and PA+P (p = 0.028). The microbial profiles of saliva and fecal samples were distinct. Mycoplasma faucium, Tannerella forsythia, Parvimonas micra, and Saccharibacteria (TM7) were increased in P; Prevotella pallens, Prevotella melaninogenica, Neisseria multispecies were more abundant in PA+P group, Ruthenibacterium lactatiformans, Dialister succinatiphilus, Butyrivibrio crossotus and Alloprevotella tannerae were detected in fecal samples in P groups compared to healthy controls. Conclusions: No significant differences were detected between Parkinson's and non-Parkinson's gut microbiomes, suggesting that Parkinson's disease modifies the oral microbiome in periodontitis subjects independent of the gut microbiome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.