ArticleTurkish journal of pharmaceutical sciences2024
Alpha Amyrin Nano-Emulsion Formulation from Stem Bark of
Article in Turkish journal of pharmaceutical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Natural Products in Gambeya lacourtiana (Sapotaceae): Identification, In Vitro Cytoxicity, and Deep Learning-Based Pharmacokinetic Prediction.Chemistry & biodiversity · 2026Article
- Physicochemical Characterization, Drug Release, Stability, and Cytotoxicity of Cross-Linked Curdlan-Based Nanosponges for α-Amyrin and Higenamine Delivery.Turkish journal of pharmaceutical sciences · 2025Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Alpha-amyrin (AA) is a pentacyclic triterpene that exhibits erratic gastrointestinal absorption and poor blood-brain barrier permeability. The study aims to isolate AA from the stem bark of Materials and Methods: AA was isolated from the stem bark of Fb by Soxhlet extraction, purified by analytical methods, prepared chitosan-decorated NE of the same, and characterized. It was then administered through IN route to aluminum-treated Swiss albino mice for 28 days to check its effect on neurobehavioral parameters. Results: IN delivery of chitosan-decorated AA, NE resulted in significant improvement in neurobehavioral parameters. It reduced the fall-off period in the rotarod test and the escape latency in the Morris water maze test, and animals showed improved learning and spatial memory in the elevated plus maze. The transfer latency of animals improved with treatment compared with the aluminum-induced groups, indicative of the neuroprotective role of the drug. Conclusion: IN administration of AA, NE isolated from the stem bark of Fb improved neurobehavioral parameters in aluminum-induced neurotoxicity in Swiss albino mice.
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Registered trials
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