Evidence map›Paper›PMID 38528588›Full record

SynthesisClinical epigenetics2024

Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health.

Hannah M Smith, Joanna E Moodie, Karla Monterrubio-Gómez, Danni A Gadd, Robert F Hillary, Aleksandra D Chybowska, Daniel L McCartney, Archie Campbell, Paul Redmond, Danielle Page and 13 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 1 country.

Hannah M SmithCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Joanna E MoodieLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Karla Monterrubio-GómezMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Danni A GaddCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Robert F HillaryCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Aleksandra D ChybowskaCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Daniel L McCartneyCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
Paul RedmondLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Danielle PageLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Adele TaylorLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Janie CorleyLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Sarah E HarrisLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Maria Valdés HernándezCentre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Susana Muñoz ManiegaCentre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Mark E BastinCentre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Joanna M WardlawCentre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Ian J DearyLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
James P BoardmanCentre for Clinical Brain Sciences, and Edinburgh Centre in the UK Dementia Research Institute, Chancellor's Building, University of Edinburgh, Little France, Edinburgh, UK.
Donncha S MullinCentre for Clinical Brain Sciences, Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
Tom C RussLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Simon R CoxLothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK.
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK. riccardo.marioni@ed.ac.uk.
Edinburgh Cancer Research · GBUniversity of Edinburgh · GBNHS Lothian · GBAlzheimer Scotland · GBMRC Institute of Genetics and Molecular Medicine · GBUK Dementia Research Institute · GB

Funding

Medical Research Council MR/X003434/1Wellcome TrustWellcome Trust 108890/Z/15/ZWellcome Trust 21843/Z/19/ZWellcome Trust 221890/Z/20/Z
6 · The paper itself

Abstract

backgroundEpigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typically derived via penalised regression, whereby a linear weighted sum of DNA methylation (DNAm) levels at CpG sites are predictive of protein levels. Here, we examine 84 previously published protein EpiScores as possible biomarkers of cross-sectional and longitudinal measures of general cognitive function and brain health, and incident dementia across three independent cohorts.

resultsUsing 84 protein EpiScores as candidate biomarkers, associations with general cognitive function (both cross-sectionally and longitudinally) were tested in three independent cohorts: Generation Scotland (GS), and the Lothian Birth Cohorts of 1921 and 1936 (LBC1921 and LBC1936, respectively). A meta-analysis of general cognitive functioning results in all three cohorts identified 18 EpiScore associations (absolute meta-analytic standardised estimates ranged from 0.03 to 0.14, median of 0.04, P

conclusionsEpiScores might make a contribution to the risk profile of poor general cognitive function and global brain health, and risk of dementia, however these scores require replication in further studies.

Indexed as

Alzheimer DiseaseDNA MethylationBiomarkersBlood ProteinsBrainCognitionCross-Sectional StudiesEpigenesis, GeneticHumansBiomarkersBlood ProteinsBlood-based biomarkersBrain imagingDementiaDNA methylationEpigenetic scoresGeneral cognitive function

Identifiers

PMID38528588
PMCPMC10962132
OpenAlexW4393159772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.