Evidence map›Paper›PMID 38528484›Full record

ArticleBMC pediatrics2024

Umbilical cord blood cell characteristics in very preterm neonates for autologous cell therapy of preterm-associated complications.

Ren Zhuxiao, Han Jiangxue, Li Yongsheng, Pei Jingjun, Yang Shuo, Xu Fang, Zhang Qi, Zhang Shandan, Nie Chuan, Yang Jie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ren Zhuxiao *Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou, 511442, China.
Han Jiangxue *Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou, 511442, China.
Li Yongsheng *Guangdong Cord Blood Bank, Guangzhou, 511440, China.
Pei Jingjun *Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 511400, China.
Yang ShuoDepartment of Medical Statistics, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China.
Xu FangDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, 511442, China.
Zhang QiDepartment of Clinic Genetic Center, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou, 511442, China.
Zhang Shandan *Department of Neonatology, The Maternal and Child Health Care Hospital of HuaDu District, GuangZhou City, Guangdong Medical University, Guangzhou, 510800, China.
Nie ChuanDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, 511442, China. chuannie@sina.com.
Yang JieDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, 511400, China. jieyang0830@126.com.
Guangdong Province Women and Children Hospital · CNGuangzhou Medical University · CNNanfang Hospital · CNGuangzhou Blood Center · CNSun Yat-sen University · CN

Funding

National Natural Science Foundation of China 2021YFC2701700National Natural Science Foundation of China 82101817Natural Science Foundation of Guangdong Province 2021A1515012121
6 · The paper itself

Abstract

backgroundThere are emerging clinical evidence for umbilical cord blood mononuclear cells (UCBMNCs) intervention to improve preterm complications. The first critical step in cell therapy is to obtain high-quality cells. This retrospective study aimed to investigate the quantity and quality of UCBMNCs from very preterm infants (VPIs) for the purpose of autologous cell therapy in prevention and treatment of preterm complications.

methodsVery preterm infants (VPIs) born in Guangdong Women and Children Hospital from January 1, 2017, to December 8, 2022, from whom cord blood was successfully collected and separated for public or private banking, were enrolled. The UCBMNCs characters from route cord blood tests performed in cord blood bank, impact of perinatal factors on UCBMNCs, the relationship between UCBMNCs characteristics and preterm outcomes, and the correlation of UCBMNCs characteristics and peripheral blood cells in VPIs were analyzed.

resultsTotally, 89 VPIs underwent UCB collection and processing successfully. The median cell number post processing was 2.6 × 10

conclusionUCBMNCs collected from VPIs was feasible for autologous cell therapy in improving preterm complications. Setting the infusion dose of 5 × 10

Indexed as

Fetal BloodInfant, Extremely PrematureChildFemaleHumansInfantInfant, NewbornLeukocyte CountLeukocytes, MononuclearPregnancyRetrospective StudiesCell therapyCord blood cellsFeasibilityOutcomesVery preterm infants

Identifiers

PMID38528484
PMCPMC10962198
OpenAlexW4393160288

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.