Evidence map›Paper›PMID 38528477›Full record

Observational studyThe journal of headache and pain2024

Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI.

Emilie Isager Howe, Nada Andelic, Cathrine Brunborg, Marina Zeldovich, Eirik Helseth, Toril Skandsen, Alexander Olsen, Silje C R Fure, Alice Theadom, Katrin Rauen and 12 more

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02210221 (Collaborative European NeuroTrauma Effectiveness Research in TBI), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02210221 completednot on this map

Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI)

Typeobservational_patient_registrySponsorUniversity Hospital, AntwerpRan2014 to 2021Enrolled4,559ConditionsTraumatic Brain Injury
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 20 institutions in 18 countries.

Emilie Isager Howe *Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway. emilie.howe@medisin.uio.no.
Nada Andelic *Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Cathrine Brunborg *Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway.
Marina ZeldovichInstitute of Psychology, University of Innsbruck, Innsbruck, Austria.
Eirik HelsethInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Toril SkandsenDepartment of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Alexander OlsenClinic of Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Silje C R FureDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Alice TheadomTBI Network, Department of Psychology, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.
Katrin RauenNeurological Rehabilitation Center Godeshöhe, Bonn, Germany.
Benedikte Å MadsenDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Bram JacobsDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joukje van der NaaltDepartment of Neurology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Cathrine Elisabeth EinarsenDepartment of Neuromedicine and Movement Science, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
Gøril StorvigClinic of Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Erling TronvikNorHEAD - Norwegian Centre for Headache Research, Trondheim, Norway.
Cathrine TverdalDepartment of Neurosurgery, Division of Emergencies and Critical Care, Department of Research and Development, Oslo University Hospital, Oslo, Norway.
Nicole von SteinbüchelInstitute of Psychology, University of Innsbruck, Innsbruck, Austria.
Cecilie RøeDepartment of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
Torgeir Hellstrøm *Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway.
CENTER-TBI Participants and Investigators
Oslo University Hospital · NONorwegian University of Science and Technology · NOUniversity Hospital of North Norway · NOAssistance Publique – Hôpitaux de Paris · FRMonash University · AUSt Olav's University Hospital · NOUniversity of Pecs · HUSan Raffaele University of Rome · ITUniversity of Oslo · NOAuckland University of Technology · NZAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITCentre Hospitalier Régional et Universitaire de Nancy · FRInnsbruck Medical University · ATKarolinska Institutet · SEKarolinska University Hospital · SEMedical University of Vienna · ATNIHR Surgical Reconstruction and Microbiology Research Centre · GBUniversität Innsbruck · ATUniversity of Groningen · NLUniversity of Szeged · HU

Funding

The European Union 7th Framework programme 602150
6 · The paper itself

Abstract

backgroundHeadache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury.

methodsA large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors.

resultsA total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury.

conclusionsHeadache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache.

trial registrationClinicalTrials.gov NCT02210221.

Indexed as

Brain Injuries, TraumaticAgedComorbidityEmergency Service, HospitalFemaleHeadacheHumansMaleProspective StudiesBrain traumaObservational studyPost-traumatic headacheSecondary headache disorders

Identifiers

PMID38528477
PMCPMC10964672
OpenAlexW4393144231

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.