Evidence map›Paper›PMID 38528468›Full record

ArticleBMC cancer2024

Accuracy of endometrial sampling in the diagnosis of endometrial cancer: a multicenter retrospective analysis of the JAGO-NOGGO.

Zaher Alwafai, Maximilian Heinz Beck, Sepideh Fazeli, Kathleen Gürtler, Christine Kunz, Juliane Singhartinger, Dominika Trojnarska, Dario Zocholl, David Johannes Krankenberg, Jens-Uwe Blohmer and 2 more

Erratum issuedOpen access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Zaher Alwafai *Department of Gynecology and Obstetrics, University of Greifswald, Greifswald, Germany.
Maximilian Heinz Beck *Young Academy of Gynecologic Oncology (JAGO), Berlin, Germany. maximilian-heinz.beck@charite.de.ORCID http://orcid.org/0000-0002-0400-0046
Sepideh FazeliYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Kathleen GürtlerYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Christine KunzYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Juliane SinghartingerYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Dominika TrojnarskaYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Dario ZochollInstitute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, corporate member of, Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
David Johannes KrankenbergDepartment of Gynecology With Breast Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
Jens-Uwe BlohmerDepartment of Gynecology With Breast Center, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, Berlin Institute of Health, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany.
Jalid SehouliYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Klaus PietznerYoung Academy of Gynecologic Oncology (JAGO), Berlin, Germany.
Humboldt-Universität zu Berlin · DEDRK Kliniken Berlin · DEGynecologic Oncology Group · USJagiellonian University · PLKrankenhaus St. Elisabeth und St. Barbara · DEKrankenhaus Waldfriede · DEKreisklinik Trostberg · DEUniversität Greifswald · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate preoperative molecular and histological risk stratification is essential for effective treatment planning in endometrial cancer. However, inconsistencies between pre- and postoperative tumor histology have been reported in previous studies. To address this issue and identify risk factors related to inaccurate histologic diagnosis after preoperative endometrial evaluation, we conducted this retrospective analysis.

methodsWe conducted a retrospective analysis involving 375 patients treated for primary endometrial cancer in five different gynaecological departments in Germany. Histological assessments of curettage and hysterectomy specimens were collected and evaluated.

resultsPreoperative histologic subtype was confirmed in 89.5% of cases and preoperative tumor grading in 75.2% of cases. Higher rates of histologic subtype variations (36.84%) were observed for non-endometrioid carcinomas. Non-endometrioid (OR 4.41) histology and high-grade (OR 8.37) carcinomas were identified as predictors of diverging histologic subtypes, while intermediate (OR 5.04) and high grading (OR 3.94) predicted diverging tumor grading.

conclusionWhen planning therapy for endometrial cancer, the limited accuracy of endometrial sampling, especially in case of non-endometrioid histology or high tumor grading, should be carefully considered.

Indexed as

CarcinomaCarcinoma, EndometrioidEndometrial NeoplasmsEndometriumFemaleHumansHysterectomyNeoplasm GradingNeoplasm StagingRetrospective StudiesAccuracyDiagnosisEndometrial cancerEndometrial sampling

Identifiers

PMID38528468
PMCPMC10964509
OpenAlexW4393161897

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.