Evidence map›Paper›PMID 38528292›Full record

ArticleHepatology international2024

Global burden and trends of acute viral hepatitis among children and adolescents from 1990 to 2019: a systematic analysis of the Global Burden of Disease Study 2019.

Wanglong Xiao, Jingwei Zhao, Yiwen Chen, Xingzhu Liu, Chang Xu, Jiaxu Zhang, Yongbing Qian, Qiang Xia

Abstract read
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In one paragraph

Article in Hepatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wanglong XiaoDepartment of Liver Surgery, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai, 200127, China.
Jingwei ZhaoDepartment of General Surgery, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yiwen ChenDepartment of Liver Surgery, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai, 200127, China.
Xingzhu LiuSchool of Biological and Biomedical Sciences, Queen Mary University of London, London, UK.
Chang XuSchool of Biological and Biomedical Sciences, Queen Mary University of London, London, UK.
Jiaxu ZhangDepartment of Liver Surgery, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai, 200127, China.
Yongbing QianDepartment of Liver Surgery, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai, 200127, China. qianyb79@hotmail.com.ORCID http://orcid.org/0000-0003-4081-428X
Qiang XiaDepartment of Liver Surgery, School of Medicine, Renji Hospital, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai, 200127, China. xiaqiang@shsmu.edu.cn.

Funding

Medical Innovation Research Special Project of Shanghai Science and Technology Innovation Action 22Y2190040Shanghai Jiaotong University High Level Project KJ2-0101-22-1200Shanghai Key Research Center Class A 2022ZZ01016
6 · The paper itself

Abstract

backgroundChildren and adolescents are at high risk for acute viral hepatitis (AVH), but epidemiological research focusing on them has been overshadowed by adult chronic B and C. We provide global, regional, and national estimates of the AVH burden and their trends on people under 20 years from 1990 to 2019.

methodsAVH data from Global Burden of Disease Study (GBD) 2019 was used. Incidence and disability-adjusted life years (DALYs) were calculated, analyzing trends with estimated annual percentage change (EAPC) and Joinpoint regression.

resultsIn 2019, 156.39 (95% uncertainty interval 145.20-167.16) million new cases of AVH were reported among children and adolescents globally, resulting in 1.98 (1.50-2.55) million DALYs. Incidence rates for young children (< 5 years), older children (5-9 years), and adolescents (10-19 years) were 12,799 (11,068-14,513), 5,108 (4829-5411), and 3020 (2724-3339) per 100,000 population, respectively. The global AVH incidence displayed a linear decline with an EAPC of - 0.66 (- 0.68 to - 0.65). High-incidence regions included sub-Saharan Africa, Oceania, South Asia, and Central Asia, with India, Pakistan, and Nigeria facing the greatest burden. Leading causes were hepatitis A, followed by hepatitis E, B, and C. All hepatitis types showed declining trends, especially hepatitis B. Furthermore, we confirmed the association between the AVH incidence and the socioeconomics, vaccine, and advanced liver diseases.

conclusionEffective vaccines and treatments for hepatitis B and C offer eradication opportunities. Broadening diagnostic and therapeutic coverage is vital to address disparities in service provision for children and adolescents.

Indexed as

Global Burden of DiseaseHepatitis, Viral, HumanAcute DiseaseAdolescentChildChild, PreschoolDisability-Adjusted Life YearsFemaleGlobal HealthHumansIncidenceInfantMaleYoung AdultDisability-adjusted life yearsGBD StudyGlobal healthHAVHBVHCVHEVIncidencePediatric populationViral infections

Identifiers

PMID38528292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.