Evidence map›Paper›PMID 38528282›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Association between fatigue and MDS-UPDRS in individuals with Parkinson's disease: cross-sectional study.

Marcelle Brandão Terra, Josiane Lopes, Maria Eduarda Brandão Bueno, Luzia Aparecida Trinca, Suhaila Mahmoud Smaili

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Association of fatigue and other non-motor and motor symptoms in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  2. Review
  3. Behavioral disorders in Parkinson disease: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marcelle Brandão TerraNeurofunctional Physical Therapy Research Group (GPFIN), Graduate program in Rehabilitation Sciences - State University of Londrina, Londrina, Paraná, Brazil. marcelleterra@uel.br.ORCID http://orcid.org/0000-0003-3976-2048
Josiane LopesDepartment of Physiotherapy, State University of Midwest, Guarapuava, Paraná, Brazil.
Maria Eduarda Brandão BuenoNeurofunctional Physical Therapy Research Group (GPFIN), Graduate program in Rehabilitation Sciences - State University of Londrina, Londrina, Paraná, Brazil.
Luzia Aparecida TrincaDepartment of Biodiversity Biostatistics - State, Institute of Biosciences, University of Sao Paulo (UNESP), Botucatu, São Paulo, Brazil.
Suhaila Mahmoud SmailiDepartment of Physiotherapy, Neurofunctional Physical Therapy Research Group (GPFIN), Master's and Doctoral degree program in Rehabilitation Sciences - State University of Londrina, Londrina, Paraná, Brazil.ORCID http://orcid.org/0000-0002-9048-9799
Universidade Estadual de Londrina · BRUniversidade de São Paulo · BRUniversidade Estadual do Paraná · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

backgroundFatigue is significant in the context of Parkinson's disease (PD), considering that one-third of patients classify it as the most restricting symptom in their daily life activities (DLAs). The objective was to verify the relationship (association) between fatigue and non-motor and motor symptoms of PD.

methodsA cross-sectional study which included 100 individuals with PD. Initially, demographic and clinical data (modified Hoehn and Yahr scale-HY, anxiety, and depression) were collected. To assess the non-motor and motor symptoms of PD, the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) was applied. Fatigue was evaluated using the Parkinson Fatigue Scale.

resultsA higher HY score, greater severity of non-motor aspects of DLAs and motor aspects of DLAs, more motor complications, and higher levels of anxiety as well as depression were observed in the "fatigue" group. Fatigue was associated with a lower daily equivalent levodopa dose (LEDD), a higher body mass index (BMI), anxiety, depression, and the presence of non-motor symptoms.

conclusionNon-motor symptoms are more determining factors for fatigue than the motor condition itself, with an association between fatigue and higher BMI scores, increased anxiety and depression, lower LEDD, and greater severity of non-motor aspects of DLAs. Individuals in the "fatigue" group had higher HY scores, anxiety, and depression, worse non-motor and motor symptoms related to experiences of daily life, as well as motor complications.

Indexed as

FatigueParkinson DiseaseSeverity of Illness IndexActivities of Daily LivingAgedAnxietyCross-Sectional StudiesDepressionFemaleHumansLevodopaMaleMiddle AgedLevodopaFatigueNon-motor symptomsParkinson’s diseaseSigns and Symptoms

Identifiers

PMID38528282
OpenAlexW4393183227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.