ArticleJA clinical reports2024
Amino acids to prevent cardiac surgery-associated acute kidney injury: a randomized controlled trial.
Article in JA clinical reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Intravenous amino acids for kidney protection in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials.The Journal of international medical research · 2025Pooled it
- Trial sequential analysis of the efficacy of amino acid and protein therapy in preventing cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2026Review
- Intravenous amino acids to prevent acute kidney injury in cardiac surgery with cardiopulmonary bypass: a meta-analysis of randomized controlled trials.International journal of cardiology. Heart & vasculature · 2026Article
- Amino acids for renal protection: time to implement in clinical practice.Korean journal of anesthesiology · 2026Review
- Amino acids for the prevention of acute kidney injury after cardiac surgery: a narrative review of trials and meta-analyses.Journal of cardiothoracic surgery · 2026Review
- Perioperative acute kidney injury: current prevention, detection, and management strategies.Journal of anesthesia · 2026Review
- Hepato-renal Protective Effect of Glutamine in Oxidative Stress Rat Model by Elevating the Glutamine-Glutathione Axis.International journal of preventive medicine · 2026Article
- The role of amino acids and protein administration in preventing cardiac surgery-associated acute kidney injury.Future cardiology · 2025Review
- Intravenous amino acid for kidney protection: current understanding and future perspectives.Clinical kidney journal · 2025Review
- Impacts of amino acid supplementation on renal function and nutritional parameters in patients with renal insufficiency: bibliometric analysis and meta-analysis.Frontiers in nutrition · 2025Review
- A new perspective on amino acid infusion: from perioperative parenteral nutrition to renal protection.JA clinical reports · 2024Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to examine the preventive effect of amino acids on postoperative acute kidney injury (AKI).
methodsThis was single-center, patient- and assessor-blinded, randomized controlled trial. Patients who underwent aortic surgery with cardiopulmonary bypass were included. The intervention group received 60 g/day of amino acids for up to 3 days. The control group received standard care. The primary outcome was the incidence of AKI. We assessed the effect of amino acids on AKI using a Cox proportional hazards regression model.
resultsSixty-six patients were randomly assigned to the control or intervention group. One patient in the control group withdrew consent after randomization. The incidence of AKI was 10 patients (30.3%) in the intervention group versus 18 patients (56.2%) in the control group (adjusted hazard ratio, 0.44; 95% confidence interval, 0.20-0.95; P = 0.04).
conclusionsThis trial demonstrated a significant reduction in AKI incidence with amino acid supplementation.
trial registrationjRCT, jRCTs051210154. Registered 31 December 2021, https://jrct.niph.go.jp/re/reports/detail/69916.
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