Evidence map›Paper›PMID 38528164›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2024

Dosimetry and pharmacokinetics of [

Seval Beykan Schürrle, Uta Eberlein, Catherine Ansquer, Jean-Mathieu Beauregard, Lucie Durand-Gasselin, Henning Grønbæk, Alexander Haug, Rodney J Hicks, Nat P Lenzo, Shaunak Navalkissoor and 6 more

Registry-linked trialOpen access · hybridAbstract readClinical Trial, Phase IClinical Trial, Phase II
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02592707 (An International, Multicenter, Open-label Study to Evaluate Safety, Tolerability, Biodistribution, Dosimetry and Preliminary Efficacy of 177Lu-OPS201 for the Therapy of Somatostatin Receptor-positive Neuroendocrine Tumors), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02592707 phase1 / phase2terminatednot on this map

An International, Multicenter, Open-label Study to Evaluate Safety, Tolerability, Biodistribution, Dosimetry and Preliminary Efficacy of 177Lu-OPS201 for the Therapy of Somatostatin Receptor-positive Neuroendocrine Tumors (NETs)

TypeinterventionalSponsorIpsenRan2017 to 2022Enrolled40ConditionsNeuroendocrine TumorsArmsSatoreotide tetraxetan, Amino acid solution, Antiemetic
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Malignancy Detection Rates of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  3. Targeted βJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Trial
  4. Review
  5. Krenning score enhances integrated biomarker models for survival prediction in PRRT-treated GEP-NET: a retrospective cohort study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026
    Article
  6. Article
  7. Combination therapy strategies in engineeredCell communication and signaling : CCS · 2026
    Review
  8. Review
  9. Review
  10. Comparison of the tolerability ofEuropean journal of nuclear medicine and molecular imaging · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 8 countries.

Seval Beykan Schürrle *Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Uta Eberlein *Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Catherine AnsquerCHU Nantes, Nantes Université, Médecine Nucléaire, Nantes, France.
Jean-Mathieu BeauregardDepartment of Medical Imaging, CHU de Québec - Université Laval, Québec City, QC, Canada.
Lucie Durand-GasselinIpsen Innovation, Les Ulis, France.
Henning GrønbækDepartment of Hepatology & Gastroenterology, ENETS Centre of Excellence, Aarhus University Hospital and Clinical Institute, Aarhus University, Aarhus, Denmark.
Alexander HaugDepartment of Radiology and Nuclear Medicine, Medical University of Vienna, Vienna, Austria.
Rodney J HicksDepartment of Medicine, St Vincent's Hospital, The University of Melbourne, Melbourne, VIC, Australia.
Nat P LenzoGenesisCare, East Fremantle, WA, Australia.
Shaunak NavalkissoorNeuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free London NHS Foundation Trust, London, UK.
Guillaume P NicolasDivision of Nuclear Medicine, ENETS Centre of Excellence, University Hospital Basel, Basel, Switzerland.
Ben PaisSRT-Biomedical B.V, Soest, Netherlands. b.pais@ariceum-therapeutics.com.
Magali VolteauIpsen Innovation, Les Ulis, France.
Damian WildDivision of Nuclear Medicine, ENETS Centre of Excellence, University Hospital Basel, Basel, Switzerland.
Alexander McEwanAriceum Therapeutics GmbH, Berlin, Germany.
Michael LassmannDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Universitätsklinikum Würzburg · DEIpsen (France) · FRUniversity Hospital of Basel · CHAarhus University Hospital · DKAustralian and New Zealand Intensive Care Society · AUMedical University of Vienna · ATNantes Université · FRRoyal Free London NHS Foundation Trust · GBThe Alfred Hospital · AUUniversité Laval · CA

Funding

Ipsen Ipsen
6 · The paper itself

Abstract

purposeTo evaluate the dosimetry and pharmacokinetics of the novel radiolabelled somatostatin receptor antagonist [

methodsThis study was part of a phase I/II trial of [

resultsIn all evaluated organs, maximum [

conclusion[

trial registrationNCT02592707. Registered October 30, 2015.

Indexed as

Neuroendocrine TumorsAdultAgedAged, 80 and overDisease ProgressionFemaleHumansLutetiumMaleMiddle AgedOctreotideRadioisotopesRadiometryRadiopharmaceuticalsSomatostatinTissue DistributionLutetiumLutetium-177OctreotideRadioisotopesRadiopharmaceuticalsSomatostatin[177Lu]Lu-satoreotide tetraxetanDosimetryNeuroendocrine tumoursPharmacokineticsSomatostatin receptor antagonistSystemic radionuclide therapy

Identifiers

PMID38528164
PMCPMC11178655
OpenAlexW4394764806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.