ArticleNature chemistry2024
Silicon-RosIndolizine fluorophores with shortwave infrared absorption and emission profiles enable in vivo fluorescence imaging.
Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 80 citations in OpenAlex.
- Colloidal InSb Quantum Dots for eSWIR Photodetection via Decoupling Nucleation and Growth.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Silicon Flavylium Polymethine Dyes for Shortwave Infrared Imaging.Journal of the American Chemical Society · 2026Article
- Fluorescent J‑Aggregates in the NIR-II Window: Unlocking Frontiers in Biomedical Imaging.Chemical & biomedical imaging · 2026Review
- Precise discrimination of G-quadruplex conformation by chiral nanoassembly with photo-reversibility.Nature communications · 2026Article
- Asymmetric Xanthene with Noncovalent Conformation Locks to Attain High Fluorescence >1500 nm.Journal of the American Chemical Society · 2026Article
- Chromenylium and Flavylium Polymethine Fluorophores Light Up the Shortwave Infrared Region.Accounts of chemical research · 2026Article
- Gold Quantum Rods Emit in the Shortwave Infrared (1000-2200 nm) with 10Journal of the American Chemical Society · 2026Article
- Above the Energy Gap Law: Heavy Chalcogenide Substitution in NIR II-Emissive Diradicaloid Qubits.ACS central science · 2025Article
- Near-Infrared-II Fluorescence Imaging of Tumors with Organic Small-Molecule Fluorophores.Sensors (Basel, Switzerland) · 2025Review
- Hybrid of Indolizine and Merocyanine-A New Class of Organelle-Specific Dyes.Angewandte Chemie (International ed. in English) · 2025Article
- Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction.Nature communications · 2025Article
- Energy Gap Law-Harnessing Design of Highly Second Near-Infrared Emissive 34π-Annulated Porphyrinoids for In Vivo Imaging.Journal of the American Chemical Society · 2025Article
- Size-tuned PEGylated NIR-II fluorescent probes for high-contrast plant imaging and TMV detection.Journal of nanobiotechnology · 2025Article
- Recent advances in NIR-II photothermal and photodynamic therapies for drug-resistant wound infections.Materials today. Bio · 2025Article
- Rationally designed NIR-II excitable and endoplasmic reticulum-targeted molecular phototheranostics for imaging-guided enhanced photoimmunotherapy of triple-negative breast cancer.Journal of nanobiotechnology · 2025Article
- A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging.Nature communications · 2025Article
- Quantum Chemical Determination of Molecular Dye Candidates for Non-Invasive Bioimaging.Molecules (Basel, Switzerland) · 2024Article
- Extended shortwave infrared absorbing antiaromatic fluorenium-indolizine chromophores.Chemical science · 2024Article
- Fused Double Donor Design with a Cross-Conjugated Dibenzosilin for Dye-Sensitized Solar Cells.ACS omega · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
In vivo fluorescence imaging in the shortwave infrared (SWIR, 1,000-1,700 nm) and extended SWIR (ESWIR, 1,700-2,700 nm) regions has tremendous potential for diagnostic imaging. Although image contrast has been shown to improve as longer wavelengths are accessed, the design and synthesis of organic fluorophores that emit in these regions is challenging. Here we synthesize a series of silicon-RosIndolizine (SiRos) fluorophores that exhibit peak emission wavelengths from 1,300-1,700 nm and emission onsets of 1,800-2,200 nm. We characterize the fluorophores photophysically (both steady-state and time-resolved), electrochemically and computationally using time-dependent density functional theory. Using two of the fluorophores (SiRos1300 and SiRos1550), we formulate nanoemulsions and use them for general systemic circulatory SWIR fluorescence imaging of the cardiovascular system in mice. These studies resulted in high-resolution SWIR images with well-defined vasculature visible throughout the entire circulatory system. This SiRos scaffold establishes design principles for generating long-wavelength emitting SWIR and ESWIR fluorophores.
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