Evidence map›Paper›PMID 38528000›Full record

ArticleScientific reports2024

Synthesis, characterization of poly L(+) lactic acid and its application in sustained release of isosorbide dinitrate.

El-Refaie Kenawy, A M Abd El Hay, Nermeen Saad, Mohamed M Azaam, Kamel R Shoueir

Abstract read
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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

El-Refaie KenawyPolymer Research Group, Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt. ekenawy@science.tanta.edu.eg.
A M Abd El HayChemistry Department, Faculty of Science, Al Azhar University, Cairo, Egypt.
Nermeen SaadPolymer Research Group, Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Mohamed M AzaamPolymer Research Group, Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Kamel R ShoueirInstitute of Nanoscience and Nanotechnology, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt. kamel_rezk@nano.kfs.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly L(+) lactic acid (PLLA) has become crucial in the biomedical industry for various uses. The direct polycondensation method was used to prepare Poly L(+) Lactic Acid (PLLA). Different catalysts, including metal oxides and metal halides, were used to test the polymerization technique. The effect of the amount of catalysts and the type of coupling agent were investigated. The effect of reaction time and polymerization solvents was also studied. PLLA was loaded with isosorbide dinitrate utilizing the solvent evaporation process. The synthesized polymer-drug system was evaluated by different means such as FT-IR, TGA, DSC, XRD, entrapment efficiency (E.E), drug loading (D.L), particle size analysis, and zeta potential determination. Studies on in-vitro release using UV light at 227 nm at various pH levels were conducted, and the kinetics of release and cytotoxicity using the sulforhodamine B (SRB) assay on human skin fibroblast cells were examined.

Indexed as

Isosorbide dinitrateKineticsNanoencapsulationPolycondensation polymerizationPoly l(+) lactic acidSustained release

Identifiers

PMID38528000
PMCPMC10963719

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.