Evidence map›Paper›PMID 38527666›Full record

ArticleBiochimica et biophysica acta. Molecular and cell biology of lipids2024

The unusual substrate specificity of Escherichia coli cardiolipin synthase C does not require the product of the transcriptionally engaged ymdB gene.

Katsuhiro Sawasato, Mikhail Bogdanov

Abstract read
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In one paragraph

Article in Biochimica et biophysica acta. Molecular and cell biology of lipids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Dark Side ofJournal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Katsuhiro SawasatoDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center, McGovern Medical School, Houston, TX 77030, USA. Electronic address: Katsuhiro.Sawasato@uth.tmc.edu.
Mikhail BogdanovDepartment of Biochemistry and Molecular Biology, the University of Texas Health Science Center, McGovern Medical School, Houston, TX 77030, USA. Electronic address: mikhail.v.bogdanov@uth.tmc.edu.

Funding

Protein sequence determinants and properties of the lipid bilayer that govern membrane protein dynamic organizationR01GM121493 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOGDANOV, MIKHAIL V., DOWHAN, WILLIAM · 2017 to 2025
$3.6M
NIGMS NIH HHS R01 GM121493
6 · The paper itself

Abstract

Polycistronic transcription and translation of ymdB-clsC have been thought to be required for full activity of ClsC. The authentic initiation codon of the clsC gene is present within the open reading frame of the upstream located ymdB gene. ClsC translated from authentic initiation codon drives cardiolipin (CL) synthesis without transcriptionally paired YmdB. YmdB is not necessary for the substrate specificity of ClsC utilizing phosphatidylethanolamine (PE) as a co-substrate.

Indexed as

CardiolipinsEscherichia coli ProteinsTransferases (Other Substituted Phosphate Groups)Carrier ProteinsEscherichia coliMembrane ProteinsPhosphatidylethanolaminesSubstrate SpecificityTranscription, GeneticCardiolipinscardiolipin synthetaseCarrier ProteinsEscherichia coli ProteinsMembrane ProteinsphosphatidylethanolaminePhosphatidylethanolaminesTransferases (Other Substituted Phosphate Groups)YmdB protein, E coliCardiolipinCardiolipin synthase CclsCGene regulationPolycistronic operonTranslation initiation codon

Identifiers

PMID38527666
PMCPMC11678504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.