Evidence map›Paper›PMID 38527522›Full record

ReviewJournal of hepatology2024

Acute kidney injury in patients with cirrhosis: Acute Disease Quality Initiative (ADQI) and International Club of Ascites (ICA) joint multidisciplinary consensus meeting.

Mitra K Nadim, John A Kellum, Lui Forni, Claire Francoz, Sumeet K Asrani, Marlies Ostermann, Andrew S Allegretti, Javier A Neyra, Jody C Olson, Salvatore Piano and 23 more

Registry-linked trialOpen access · hybridAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06525623 (Initial Resuscitation for Acute Kidney Injury in Patients With Cirrhosis), which is not on this map. Cited by 106 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 2 pooled it
55.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06525623 narecruitingnot on this map

Initial Resuscitation for Acute Kidney Injury in Patients With Cirrhosis: A Pilot Randomized Trial Using a Volume Assessment Guidance Algorithm

TypeinterventionalSponsorMassachusetts General HospitalRan2024 to 2027Enrolled50ConditionsCirrhosis, Liver, Acute Kidney Injury, Hepatorenal SyndromeArmsRecommendation: No Further Resuscitation, Recommendation: Resuscitation with Crystalloid, Recommendation: Resuscitation with Colloid, Recommendation: Standard of Care IV Albumin
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Influence of Albumin Treatment Duration on Outcome of Terlipressin Therapy in Patients With HRS-AKI.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Observational
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
  18. Review
  19. Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 11 countries.

Mitra K NadimDivision of Nephrology and Hypertension, Keck School of Medicine, University of Southern California, Los Angeles, USA.
John A KellumCenter for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA, USA.
Lui ForniSchool of Medicine, University of Surrey and Critical Care Unit, Royal Surrey Hospital Guildford UK.
Claire FrancozHepatology & Liver Intensive Care, Hospital Beaujon, Clichy, Paris, France.
Sumeet K AsraniBaylor University Medical Center, Dallas, Texas, USA.
Marlies OstermannKing's College London, Guy's & St Thomas' Hospital, Department of Critical Care, London, UK.
Andrew S AllegrettiDivision of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Javier A NeyraDivision of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jody C OlsonDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Salvatore PianoUnit of Internal Medicine and Hepatology, Department of Medicine - DIMED, University and Hospital of Padova, Padova, Italy.
Lisa B VanWagnerDivision of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Elizabeth C VernaDivision of Digestive and Liver Diseases, Columbia University, New York, NY, USA.
Ayse Akcan-ArikanDepartment of Pediatrics, Divisions of Critical Care Medicine and Nephrology, Baylor College of Medicine, Houston, TX, USA.
Paolo AngeliUnit of Internal Medicine and Hepatology, University and Teaching Hospital of Padua, Italy.
Justin M BelcherSection of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA.
Scott W BigginsDivision of Gastroenterology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Akash DeepPediatric Intensive Care Unit, King's College Hospital, London, UK.
Guadalupe Garcia-TsaoDigestive Diseases Section, Yale University School of Medicine, New Haven, CT, USA; VA Connecticut Healthcare System, West Haven, CT, USA.
Yuri S GenykDivision of Abdominal Organ Transplantation and Hepatobiliary Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Division of Abdominal Organ Transplantation at Children's Hospital of Los Angeles, Los Angeles, CA, USA.
Pere GinesLiver Unit, Hospital Clínic de Barcelona, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi-Sunyer and Ciber de Enfermedades Hepàticas y Digestivas, Barcelona, Catalonia, Spain.
Patrick S KamathDivision of Gastroenterology and Hepatology Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Sandra L Kane-GillDepartment of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA.
Manish KaushikDepartment of Renal Medicine, Singapore General Hospital, Singapore.
Nuttha LumlertgulExcellence Centre in Critical Care Nephrology and Division of Nephrology, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Etienne MacedoDivision of Nephrology, Department of Medicine, University of California San Diego, CA, USA.
Rakhi MaiwallDepartment of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.
Sebastian MarcianoLiver Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Raimund H PichlerDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
Claudio RoncoInternational Renal Research Institute of Vicenza, Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza-Italy.
Puneeta TandonDivision of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Alberta, Canada.
Juan-Carlos Q VelezDepartment of Nephrology, Ochsner Health, New Orleans, LA, USA; Ochsner Clinical School, The University of Queensland, Brisbane, QLD, Australia.
Ravindra L MehtaDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
François DurandHepatology & Liver Intensive Care, Hospital Beaujon, Clichy, Paris, France; University Paris Cité, Paris, France. Electronic address: francois.durand@bjn.aphp.fr.
University of Pittsburgh · USUniversity of California San Diego · USUniversity of Padua · ITUniversity of Southern California · USYale University · USBaylor College of Medicine · USBaylor University Medical Center · USColumbia University · USHôpital Beaujon · FRHospital Clínic de Barcelona · ESHospital Italiano de Buenos Aires · ARInstitute of Liver and Biliary Sciences · INInternational Renal Research Institute of Vicenza · ITKing Chulalongkorn Memorial Hospital · THKing's College Hospital · GBMassachusetts General Hospital · USMayo Clinic · USMayo Clinic in Arizona · USOchsner Health System · USRoyal Surrey County Hospital · GB

Funding

Personalizing Therapies for Acute Kidney Injury in CirrhosisK23DK128567 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew S Allegretti · 2022 to 2026
$982k
NIDDK NIH HHS K23 DK128567
6 · The paper itself

Abstract

Patients with cirrhosis are prone to developing acute kidney injury (AKI), a complication associated with a markedly increased in-hospital morbidity and mortality, along with a risk of progression to chronic kidney disease. Whereas patients with cirrhosis are at increased risk of developing any phenotype of AKI, hepatorenal syndrome (HRS), a specific form of AKI (HRS-AKI) in patients with advanced cirrhosis and ascites, carries an especially high mortality risk. Early recognition of HRS-AKI is crucial since administration of splanchnic vasoconstrictors may reverse the AKI and serve as a bridge to liver transplantation, the only curative option. In 2023, a joint meeting of the International Club of Ascites (ICA) and the Acute Disease Quality Initiative (ADQI) was convened to develop new diagnostic criteria for HRS-AKI, to provide graded recommendations for the work-up, management and post-discharge follow-up of patients with cirrhosis and AKI, and to highlight priorities for further research.

Indexed as

Acute Kidney InjuryHepatorenal SyndromeLiver CirrhosisAscitesConsensusHumansacute disease quality initiativeacute kidney injuryalbuminascitesbiomarkercirrhosishepatorenal syndromeinternational club of ascitesliver transplantationrenal replacement therapyterlipressin

Identifiers

PMID38527522
PMCPMC11193657
OpenAlexW4393204019

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.