Evidence map›Paper›PMID 38527227›Full record

ReviewLaboratory medicine2024

DNA variants detected in primary and metastatic lung adenocarcinoma: a case report and review of the literature.

Christina Kelly, Caitlin Raymond, Song Han, Youmin Lin, Linyijia Chen, Gengming Huang, Jianli Dong

Erratum issuedOpen access · greenAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Laboratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christina KellyJohn Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX.
Caitlin RaymondDepartment of Pathology, University of Texas Medical Branch, Galveston, TX.ORCID 0000-0001-5474-1996
Song HanDepartment of Pathology, University of Texas Medical Branch, Galveston, TX.
Youmin LinDepartment of Pathology, University of Texas Medical Branch, Galveston, TX.
Linyijia ChenDepartment of Pathology, University of Texas Medical Branch, Galveston, TX.
Gengming HuangDepartment of Pathology, University of Texas Medical Branch, Galveston, TX.
Jianli DongDepartment of Pathology, University of Texas Medical Branch, Galveston, TX.ORCID 0000-0001-8929-6132
The University of Texas Medical Branch at Galveston · US

Funding

Infectious Diseases and Inflammatory Disorders Training ProgramT35AI078878 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WANG, TIAN · 2008 to 2025
$701k
National Institute of Allergy and Infectious Diseases 5T35 AI 078878-13National Institute of Allergy and Infectious Diseases T35 Infectious Diseases and Inflammatory Disorders 5T35 AI 078878-13NIAID NIH HHS T35 AI078878
6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) has been found to have recurrent genetic abnormalities, and novel therapies targeting these aberrations have improved patient survival. In this study, specimens from benign tissue, primary tumors, and brain metastases were obtained at autopsy from a 55-year-old White female patient diagnosed with NSCLC and were examined using next-generation sequencing (NGS) and chromosomal microarray assay (CMA). No genetic aberrations were noted in the benign tissue; however, NGS identified a mutation in the KRAS proto-oncogene, GTPase (KRAS): KRAS exon 2 p.G12D in primary and metastatic tumor specimens. We observed 7 DNA copy number aberrations (CNAs) in primary and metastatic tumor specimens; an additional 7 CNAs were exclusively detected in the metastatic tumor specimens. These DNA alterations may be genetic drivers in the pathogenesis of the tumor specimen from our patient and may serve as biomarkers for the classification and prognosis of NSCLC.

Indexed as

Adenocarcinoma of LungLung NeoplasmsProto-Oncogene MasAdenocarcinomaDNA Copy Number VariationsFemaleHigh-Throughput Nucleotide SequencingHumansMiddle AgedProto-Oncogene Proteins p21(ras)KRAS protein, humanMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins p21(ras)chromosome microarrayDNA copy number abnormalitygene mutationnext-generation sequencingnon–small cell lung canceroncogenic driver

Identifiers

PMID38527227
PMCPMC11371898
OpenAlexW4393139984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.