Evidence map›Paper›PMID 38526831›Full record

ArticleHead and neck pathology2024

Reticular Myxoid Odontogenic Neoplasm with Novel STRN::ALK Fusion: Report of 2 Cases in 3-Year-Old Males.

Molly S Rosebush, Molly Housley Smith, Kitrina G Cordell, Nicholas Callahan, Waleed Zaid, Jeffrey Gagan, Justin A Bishop

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PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Molly S RosebushLouisiana State University Health Sciences Center New Orleans, 1100 Florida Avenue, New Orleans, LA, 70119, USA. mroseb@lsuhsc.edu.
Molly Housley SmithPathology & Cytology Laboratories, Inc., Lexington, KY, USA.
Kitrina G CordellLouisiana State University Health Sciences Center New Orleans, 1100 Florida Avenue, New Orleans, LA, 70119, USA.
Nicholas CallahanUniversity of Illinois at Chicago, Chicago, USA.
Waleed ZaidLouisiana State University Health Sciences Center New Orleans, 1100 Florida Avenue, New Orleans, LA, 70119, USA.
Jeffrey GaganThe University of Texas Southwestern Medical Center, Dallas, USA.
Justin A BishopThe University of Texas Southwestern Medical Center, Dallas, USA.
Louisiana State University Health Sciences Center New Orleans · USThe University of Texas Southwestern Medical Center · USExperimental Pathology Laboratories · USUniversity of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Odontogenic tumors represent a collection of entities ranging from hamartomas to destructive benign and malignant neoplasms. Occasionally, pathologists encounter gnathic lesions which clearly exhibit an odontogenic origin but do not fit within the confines of established diagnoses. Here, we describe two such odontogenic tumors, both affecting 3-year-old males. Each case presented as a destructive, radiolucent mandibular lesion composed of mesenchymal cells, some with unique multi-lobed nuclei, frequently arranged in a reticular pattern and supported by a myxoid stroma with focal laminations. Production of odontogenic hard tissues was also seen. Because of their unique microscopic features, both cases were investigated by next-generation sequencing and found to harbor the same STRN::ALK oncogene fusion. To our knowledge, these cases represent the first report of an odontogenic tumor with a STRN::ALK gene rearrangement. We propose the possibility that this neoplasm could be separate from other known odontogenic tumors. Both patients were treated with surgical resection and reconstruction. The prognosis of patients with this entity is currently uncertain but shall become more apparent over time as more cases are identified and followed.

Indexed as

Odontogenic TumorsCalmodulin-Binding ProteinsChild, PreschoolHumansMaleMembrane ProteinsNerve Tissue ProteinsOncogene FusionReceptor Protein-Tyrosine KinasesCalmodulin-Binding ProteinsMembrane ProteinsNerve Tissue ProteinsReceptor Protein-Tyrosine KinasesSTRN protein, humanALK FusionOdontogenic myxomaOdontogenic tumorsOdontomaSTRN::ALK

Identifiers

PMID38526831
PMCPMC10963713
OpenAlexW4393156191

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.