Evidence map›Paper›PMID 38526826›Full record

ArticleJournal of food and drug analysis2023

Isolation of GLP-1 enhancing indolizidine alkaloids from Boehmeria formosana.

Ching-Yi Lu, Zheng-Ying Huang, Meng-Chin Chen, Hui-Kang Liu, Shoei-Sheng Lee, Chia-Chuan Chang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food and drug analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ching-Yi LuSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan.
Zheng-Ying HuangSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan.
Meng-Chin ChenSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan.
Hui-Kang LiuNational Research Institute of Chinese Medicine, Taipei 11221, Taiwan.
Shoei-Sheng LeeSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan.
Chia-Chuan ChangSchool of Pharmacy, College of Medicine, National Taiwan University, Taipei 10050, Taiwan.
National Taiwan University · TWNational Research Institute of Chinese Medicine · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Boehmeria formosana, with its related species, demonstrates anti-glycemic effect, inhibition of HBV production, anti-cancer activities, etc. Some indolizidine alkaloids from the same genus are bioactive but sensitive to light. To overcome this problem and obtain more phenanthroindolizidine alkaloids, isolation was performed in darkness, yielding 10 new indolizidine alkaloids and 17 known compounds. Among them, seven enhanced glucagon-like receptor 1 (GLP-1) activity at 50 mM, especially 14 and 6 (3.5- and 2.3-fold than the negative control). This procedure yielded bioactive indolizidine alkaloids with novel structures.

Indexed as

AlkaloidsBoehmeriaIndolizidinesAlkaloidsIndolizidines

Identifiers

PMID38526826
PMCPMC10962671
OpenAlexW4389868215

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.