Evidence map›Paper›PMID 38526767›Full record

ReviewHead and neck pathology2024

A Comparison of Clear Cell Sarcoma to Jaw and Salivary Tumors Bearing EWS Fusions.

Ornela Xhori, Navkiran Deol, Camron M Rivera, Jason Zavras, Sophia G Weil, Hirad Zafari, Julia C Thierauf, William C Faquin, Edwin Choy, Miguel N Rivera and 3 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Ornela XhoriDepartment of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA, 02113, USA.
Navkiran DeolHarvard School of Dental Medicine, DMD'25, 188 Longwood Avenue, Boston, MA, 02115, USA. navkiran_deol@hsdm.harvard.edu.
Camron M RiveraHarvard School of Dental Medicine, DMD'25, 188 Longwood Avenue, Boston, MA, 02115, USA.
Jason ZavrasJohns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Sophia G WeilWashington University in St. Louis, St. Louis, MO, 63130, USA.
Hirad ZafariHarvard School of Dental Medicine, DMD'25, 188 Longwood Avenue, Boston, MA, 02115, USA.
Julia C ThieraufDepartment of Pathology, Massachusetts General Hospital, Boston, MA, 02113, USA.
William C FaquinDepartment of Pathology, Massachusetts General Hospital, Boston, MA, 02113, USA.
Edwin ChoyHarvard Medical School, 27 Shattuck Street, Boston, MA, 02115, USA.
Miguel N RiveraDepartment of Pathology, Massachusetts General Hospital, Boston, MA, 02113, USA.
A John IafrateDepartment of Pathology, Massachusetts General Hospital, Boston, MA, 02113, USA.
Alexandre JaquinetPrivate Practice, Geneva, Switzerland.
Maria J TroulisHarvard School of Dental Medicine, DMD'25, 188 Longwood Avenue, Boston, MA, 02115, USA.
Massachusetts General Hospital · USHarvard University · USJohns Hopkins University · USLemuel Shattuck Hospital · USWashington University in St. Louis · US

Funding

Fondation Bertarelli 228131
6 · The paper itself

Abstract

objectiveTo review tumors identified as "clear cell sarcoma" in order to determine similarities to the rare EWS fusion positive jaw and salivary gland tumors clear cell odontogenic carcinoma (CCOC) and clear cell carcinoma of the salivary gland (CCC).

methodsPubMed was used to collect all reports of clear cell sarcoma (CCS). Search parameters were "clear cell sarcoma" and "CCS." References in the publications were screened and cross-referenced. Data extracted included demographic characteristics, presenting signs and symptoms, radiographic findings, histological and immunohistochemical features and known molecular/genetic aberrations.

resultsClear cell sarcoma has several similarities to CCOC and CCC. All three tumor types have similar histologic appearances including the presence of clear cells, as well as similar genetic profiles in that all harbor an EWSR1-CREB family fusions. Additionally, these tumors appear in soft tissue as well as bone, and can have a prolonged clinical course. CCS can appear anywhere in the body, including the head and neck region. All three tumors appear to have a predilection to women, although CCS may have a slight younger age of onset as compared to CCOC and CCC (3rd vs 5th decade of life, respectively).

conclusionGaining a better understanding of the similarities and differences between these three tumors may lead to a better understanding of each one.

Indexed as

CarcinomaOdontogenic TumorsSalivary Gland NeoplasmsSarcoma, Clear CellFemaleHumansOncogene Proteins, FusionRNA-Binding Protein EWSOncogene Proteins, FusionRNA-Binding Protein EWSATF1Clear cell carcinoma of the salivary glandClear cell odontogenic carcinomaClear cellsClear cell sarcomaCREB1CREMEWSR1

Identifiers

PMID38526767
PMCPMC10963349
OpenAlexW4393159901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.