Evidence map›Paper›PMID 38526763›Full record

ArticleJournal of neurology2024

Determinants of self-perceived quality of life in mildly disabled multiple sclerosis patients: a cross-sectional study.

Silvy Pilotto, Matteo Floris, Paolo Solla, Maura Pugliatti, Ignazio Roberto Zarbo

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In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Silvy PilottoDepartment of Medical, Surgical and Experimental Medicine, University of Sassari, Sassari, Italy. pilottosilvy@gmail.com.ORCID http://orcid.org/0000-0001-7950-0136
Matteo FlorisDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.ORCID http://orcid.org/0000-0003-4385-9336
Paolo SollaDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.ORCID http://orcid.org/0000-0002-2982-0665
Maura PugliattiDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.ORCID http://orcid.org/0000-0001-9396-8683
Ignazio Roberto ZarboDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.ORCID http://orcid.org/0000-0001-8859-2335

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWhile the determinants influencing self-perceived health-related quality of life (spHRQoL) in persons with multiple sclerosis (pwMS) and severe physical impairment have been well investigated, their impact on pwMS with mild disability is poorly addressed. We aimed to investigate possible drivers of spHRQoL among Sardinian pwMS with an EDSS lower than 2.5.

methodsA sample of 87 fully ambulatory (EDSS < 2.5) pwMS were included after screening for major cognitive impairment. spHRQoL was measured with the Italian version of 36-Item Short Form Health Survey (SF-36). The Physical Component Summary (PCS) and Mental Component Summary (MCS) were used as dependent variables for univariate analysis with Cognitive Behavioral Assessment (CBA) and specific individual factors as independent variables. Subsequent multivariate general linear models (GLMs) for PCS and MCS respectively were run after stepwise regression. Normative data referring to Italian population were used for comparison.

resultsAs compared to normative data, no statistically significant difference was found for PCS, while MCS was reduced. Multivariate GLMs showed a significant association between lower PCS scores and presence of psychosomatic symptoms, older age and fatigue (p < 0.05). Furthermore, a significant association was shown between lower MCS scores and presence of anxiety (p < 0.001).

conclusionMood, presence of psychosomatic symptoms, fatigue and age can have a relevant impact on spHRQoL in people with mildly disabling MS and should be considered in the management of such individuals.

Indexed as

Multiple SclerosisQuality of LifeAdultAgedCross-Sectional StudiesFemaleHumansItalyMaleMiddle AgedPersons with DisabilitiesSelf ConceptSeverity of Illness IndexMild disabilityMultiple sclerosisSelf-perceived Quality of Life

Identifiers

PMID38526763

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.