Evidence map›Paper›PMID 38526693›Full record

SynthesisClinical reviews in allergy & immunology2024

From Skin to Solution: Exploring Epicutaneous Immunotherapy for Peanut Allergy-A Systematic Review and Meta-Analysis.

Umm E Salma Shabbar Banatwala, Muhammad Moiz Nasir, Reema Javed, Areeba Ahmed, Syed Ali Farhan, Ali Ajam

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical reviews in allergy & immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Umm E Salma Shabbar BanatwalaDow University of Health Sciences, Karachi, Pakistan. salmabanatwala@gmail.com.
Muhammad Moiz NasirDow University of Health Sciences, Karachi, Pakistan.
Reema JavedDepartment of Dermatology, Al-Mustafa Hospital and Rajput General Hospital, Karachi, Pakistan.
Areeba AhmedDepartment of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Syed Ali FarhanDepartment of Plastic and Reconstructive Surgery, Ohio State University, Columbus, OH, USA.
Ali AjamDepartment of Rheumatology and Immunology, Ohio State University, Columbus, OH, USA.
Dow University of Health Sciences · PKThe Ohio State University · USNorthwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peanut allergy is a leading cause of severe food reactions. This meta-analysis evaluates the efficacy and safety of epicutaneous immunotherapy (EPIT) compared to placebo for peanut-allergic individuals. After prospectively registering on PROSPERO, we searched three databases (PubMed, Google Scholar, and Cochrane CENTRAL) and 2 trial registries till September 2023. Analysis was conducted via RevMan where data was computed using risk ratios (RR). The Cochrane Risk of Bias tool and GRADE criteria were used to appraise and evaluate the evidence. From 4927 records, six multicenter randomized placebo-controlled trials comprising 1453 participants were included. The 250 µg EPIT group had a significant increase in successful desensitization compared to placebo (RR: 2.13 (95% C.I: 1.72, 2.64), P < 0.01, I

Indexed as

Administration, CutaneousDesensitization, ImmunologicPeanut HypersensitivityAllergensArachisHumansRandomized Controlled Trials as TopicTreatment OutcomeAllergensAllergen desensitizationEpicutaneous immunotherapyImmunotherapy for allergyPeanut allergyPeanut protein

Identifiers

PMID38526693
OpenAlexW4393157636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.