Evidence map›Paper›PMID 38526627›Full record

ArticleOdontology2024

4-Octyl itaconate promotes alveolar ridge preservation following tooth extraction.

Yanmei Du, Yanyan He, Jianli Xie, Yuxin Wang, Xiaodong Sun, Xijiao Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yanmei Du *Oral Implantology, Jinan Stamotological Hospital, Jinan, 250001, Shandong Province, China.
Yanyan He *Central Laboratory, Department of Endodontics, Jinan Stamotological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Shandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue Regeneration, Jinan, 250001, Shandong Province, China.
Jianli Xie *Department of Prosthodontics, Jinan Stamotological Hospital, Jinan, 250001, Shandong Province, China.
Yuxin WangCentral Laboratory, Department of Endodontics, Jinan Stamotological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Shandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue Regeneration, Jinan, 250001, Shandong Province, China.
Xiaodong SunGaoxin Branch of Jinan Stamotological Hospital, Jinan, 250100, Shandong Province, China. yayiyu@163.com.
Xijiao YuCentral Laboratory, Department of Endodontics, Jinan Stamotological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Shandong Provincial Health Commission Key Laboratory of Oral Diseases and Tissue Regeneration, Jinan, 250001, Shandong Province, China. sunxiaodong618@126.com.
Jinan Stomatological Hospital · CNBinzhou Medical University · CN

Funding

Jinan Medical and Health Science and Technology Development Plan 2022-1-35Jinan Medical and Health Science and Technology Development Plan 2023-1-62Jinan Science and Technology Development Plan 202328024Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China 202208010182
6 · The paper itself

Abstract

The search for medications that can effectively reduce alveolar bone loss following tooth extraction is of great interest. This study aimed to observe the roles of 4-octyl itaconate (4-OI) in RANKL-induced osteoclastogenesis of bone marrow macrophages (BMMs) in vitro. Mandibular second molars were extracted to evaluate whether 4-OI could alleviate alveolar bone loss. 4-OI inhibited RANKL-induced osteoclastogenesis and promoted Nrf2 expression in bone marrow macrophages in vitro. Positive Nrf2 expressions were observed in inflammatory cells and osteoclasts in vivo. Treatment with 4-octyl itaconate increased Nrf2 expression, resulting in reduced inflammatory infiltration and osteoclastic activity after tooth extraction. Furthermore, increased expression of OCN and enhanced-alveolar bone healing of extraction socket were observed in the 4-OI group compared to the control group. Our results suggested that 4-OI could serve as a promising pharmacologic candidate for alveolar ridge preservation by alleviating alveolar bone loss following tooth extraction in rats.

Indexed as

Alveolar Bone LossSuccinatesTooth ExtractionAlveolar ProcessAnimalsIn Vitro TechniquesMacrophagesMaleMolarNF-E2-Related Factor 2OsteoclastsOsteogenesisRANK LigandRatsRats, Sprague-DawleyWound Healing4-octyl itaconateNF-E2-Related Factor 2RANK LigandSuccinates4-octyl itaconateBone healingBone lossNrf2tooth extraction

Identifiers

PMID38526627
OpenAlexW4393155759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.