ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Global longitudinal strain in long-term risk prediction after acute coronary syndrome: an investigation of added prognostic value to ejection fraction.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed.
- Age-Related Patterns of Myocardial Recovery After Primary PCI for Acute Myocardial Infarction: A Prospective 12-Month Study.Biomedicines · 2026Article
- Strain Echocardiography in MINOCA: Diagnostic and Follow-Up Implications.Journal of clinical medicine · 2026Article
- Age-Dependent Inflammatory, Lipid, and Echocardiographic Phenotypes in Acute Myocardial Infarction: Associations with In-Hospital Adverse Clinical Events.Biomedicines · 2026Article
- Predictive value of left ventricular global longitudinal strain for mid-term major adverse cardiovascular events in patients with atrial fibrillation complicated by acute myocardial infarction.BMC cardiovascular disorders · 2026Article
- Growth differentiation factor-15 improves long-term mortality risk prediction beyond the GRACE 2.0 score after acute coronary syndrome.Scientific reports · 2026Article
- Long-term prognostic impact of one-year change in left ventricular function after a myocardial infarction: insights from the REBUS cohort.European heart journal. Imaging methods and practice · 2026Article
- Development and validation of a long-term mortality prediction model in acute coronary syndrome survivors: a study of a predominantly male, lower-risk cohort with the capacity to complete cardiopulmonary exercise testing.BMC cardiovascular disorders · 2025Article
- Hemodynamic Markers Predict Outcomes a Decade After Acute Coronary Syndrome.Journal of clinical medicine · 2025Article
- Value of high-density lipoprotein cholesterol, myocardial perfusion index, and global longitudinal strain derived from cardiac magnetic resonance imaging in predicting coronary slow flow in patients with nonobstructive coronary artery disease.Quantitative imaging in medicine and surgery · 2025Article
- Long-Term Prognosis in Patients with ST-Elevation Myocardial Infarction Complicated by Heart Failure with Preserved Left Ventricular Ejection Fraction.Journal of cardiovascular development and disease · 2025Article
- Short-term outcomes of non-ST segment elevation acute coronary syndrome after percutaneous coronary intervention: a single-center speckle tracking echocardiographic study in Vietnam.Frontiers in cardiovascular medicine · 2025Article
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6 authors.
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Abstract
aimsThis study aimed to investigate the additional value of global longitudinal strain (GLS) on top of left ventricular ejection fraction (LVEF) in long-term risk prediction of combined death and heart failure (HF) re-hospitalization after acute coronary syndrome (ACS). METHOD AND
resultsThis retrospective study included patients admitted with ACS between 2008 and 2014 from the three participating university hospitals. LVEF and GLS were assessed at a core lab from images acquired during the index hospital stay. Their prognostic value was studied with the Cox proportional hazards model (median follow-up 6.2 years). A nested model comparison was performed with C-statistics. A total of 941 patients qualified for multivariable analysis after multiple imputation of missing baseline covariables. The combined outcome was reached in 17.7% of the cases. Both GLS and LVEF were independent predictors of the combined outcome, hazard ratio (HR) 1.068 (95% CI 1.017-1.121) and HR 0.980 (95% CI 0.962-0.998), respectively. The C-statistic increased from 0.742 (95% CI 0.702-0.783) to 0.749 (95% CI 0.709-0.789) (P = 0.693) when GLS entered the model with clinical data and LVEF.
conclusionGLS emerged as an independent long-term risk predictor of all-cause death and HF re-hospitalization. However, there was no significant incremental predictive value of GLS when LVEF was already known.
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